Browsing by Author "Leonard, David A."

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Clinical variants of the native class d beta-lactamase of acinetobacter baumannii pose an emerging threat through ıncreased hydrolytic activity against carbapenems

Schroder, Emma C.; Klamer, Zachary L.; Saral, Ayşegül; Sugg, Kyle A.; June, Cynthia M.; Wymore, Troy; Szarecka, Agnieszka; Leonard, David A. (Amer Soc Microbiology, 2016)

The threat posed by the chromosomally encoded class D beta-lactamase of Acinetobacter baumannii (OXA-51/66) has been unclear, in part because of its relatively low affinity and turnover rate for carbapenems. Several hundred ...
Kinetic characterization of GES-22 beta-lactamase harboring the M169L clinical mutation

Saral, Ayşegül; Leonard, David A.; Düzgün, Azer Özad; Çopur Çiçek, Aysegül; June, Cynthia M.; Sandallı, Cemal (Japan Antibiotics Research Assoc, 2016)

The class A p-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ...