Browsing by Author "Uğurel, Osman Mutluhan"

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Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13)

Uğurel, Osman Mutluhan; Mutlu, Özal; Sarıyer, Emrah; Koçer, Sinem; Uğurel, Erennur; İnci, Tuğba Gül; Ata, Oğuz; Turgut Balık, Dilek (Elsevier BV, 2020)

SARS-CoV-2 has caused COVID-19 outbreak with nearly 2 M infected people and over 100K death worldwide, until middle of April 2020. There is no confirmed drug for the treatment of COVID-19 yet. As the disease spread fast ...
Heterologous expression, biochemical characterisation and computational analysis of Bacteroides fragilis enolase

Uğurel, Erennur; Koçer, Sinem; Sarıyer, Emrah; Mutlu, Özal; İnci, Tuğba Gül; Uğurel, Osman Mutluhan; Turgut Balık, Dilek (Elsevier Ltd, 2022)

Bacteriodes fragilis is an anaerobic bacterium found in the human intestinal flora. In this study, BfEno was targeted with a structure-based drug design approach because inhibition of this enzyme may prevent both the aerobic ...
Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: anin silicostructure-based approach

Mutlu, Özal; Uğurel, Osman Mutluhan; Sarıyer, Emrah; Ata, Oğuz; İnci, Tuğba Gül; Uğurel, Erennur (Taylor & Francis Inc, 2020)

In this study, the Nsp12-Nsp8 complex of SARS-CoV-2 was targeted with structure-based and computer-aided drug design approach because of its vital role in viral replication. Sequence analysis of RNA-dependent RNA polymerase ...