Browsing by Author "Saral, Ayşegül"
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Antimicrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections in Turkey
Çopur Çiçek, Ayşegül; Özgümüş, Osman Birol; Saral, Ayşegül; Sandallı, Cemal (Korean Society for Laboratory Medicine, 2014)We aimed to observe antimiCrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections. Two hundred sixty-eight E. coli strains were obtained from outpatients with ... -
Bazı bitki özütlerinin antibiyotik dirençli klinik izolatlara karşı antibakteriyel aktivitelerinin belirlenmesi
Aydemir, Eda (Artvin Çoruh Üniversitesi, 2021)Acinetobacter baumannii aerobik, pleomorfik ve hareketsiz bir Gram negatif basildir. Fırsatçı bir patojen olan A. baumannii özellikle uzun süre (> 90 gün) hastanede yatanlar olmak üzere bağışıklığı baskılanmış kişiler ... -
Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Çopur Çiçek, Ayşegül; Bonnin, Remy A.; Ceylan, Ayşenur; Saral, Ayşegül; Nordmann, Patrice; Sandallı, Cemal (Elsevier Science INC, 2014)Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ... -
Clinical variants of the native class d beta-lactamase of acinetobacter baumannii pose an emerging threat through ıncreased hydrolytic activity against carbapenems
Schroder, Emma C.; Klamer, Zachary L.; Saral, Ayşegül; Sugg, Kyle A.; June, Cynthia M.; Wymore, Troy; Szarecka, Agnieszka; Leonard, David A. (Amer Soc Microbiology, 2016)The threat posed by the chromosomally encoded class D beta-lactamase of Acinetobacter baumannii (OXA-51/66) has been unclear, in part because of its relatively low affinity and turnover rate for carbapenems. Several hundred ... -
Cloning, expression, and characterization of a novel CTP synthase gene from Anoxybacillus gonensis G2
Sandallı, Cemal; Saral, Ayşegül; Ülker, Serdar; Karaoğlu, Hakan; Belduz, Ali Osman; Çopur Çiçek, Ayşegül (TUBITAK Scientific & Technical Research Council Turkey, 2014)The cytidine-5'-triphosphate (CTP) synthase (EC 6.4.3.2) gene (pyrG) was cloned and sequenced from the thermophilic bacterium Anoxybacillus gonensis G2 (Ago). The gene is 1590 bp in length and encodes a protein of 530 amino ... -
Comparison of verona integron-borne metallo-β-lactamase (VIM) variants reveals differences in stability and inhibition profiles
Makena, Anne; Düzgün, Azer Özad; Brem, Jurgen; McDonough, Michael A.; Rydzik, Anna M.; Abboud, Martine I.; Çopur Çiçek, Ayşegül; Sandallı, Cemal; Schofield, Christopher J. (Amer Soc Microbiology, 2015)Metallo-beta-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. The Verona integron-borne metallo-beta-lactamase ... -
Determination of a novel integron-located variant (bla(OXA-320)) of Class D beta-lactamase in Proteus mirabilis
Çiçek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Sandallı, Cemal (Wiley, 2014)Proteus mirabilis (P. mirabilis) is one of Gram-negative pathogens encountered in clinical specimens. A clinical isolate (TRP41) of P. mirabilis was isolated from a Turkish patient in Turkey. The isolate was identified ... -
Determination of antibiotic resistance genes and virulence factors in Escherichia coli isolated from Turkish patients with urinary tract infection
Düzgün, Özer Özad; Okumuş, Funda; Saral, Ayşegül; Çopur Çiçek, Ayşegül; Cinemre, Sedanur (Soc Brasileira Medicina Tropical, 2019)Introduction: Escherichia coli ranks among the most common sources of urinary tract infections (UTI). Methods: Between November 2015 and August 2016, 90 isolates of E. coli were isolated from patients at Rize Education ... -
Distribution of beta-lactamase genes among carbapenem-resistant klebsiella pneumoniae strains isolated from patients in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Sandallı, Cemal; Doymaz, Mehmet Ziya; Akkoyunlu, Yasemin; Saral, Ayşegül; Peleg, Anton Y.; Özgümüş, Osman Birol; Beris, Osman Birol; Beris, Fatih Şaban; Karaoglu, Hakan; Çiçek, Ayşegül Çopur (Korean Society for Laboratory Medicine, 2015)Background: The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the beta-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates ... -
Escherichia coli klinik izolatlarında blaTEM, blaSHV ve blaCTX-M Genlerinin polimeraz zincir reaksiyon yöntemiyle belirlenmesi
Kaya, Ersin (Artvin Çoruh Üniversitesi, 2019)Bilinçsiz antibiyotik kullanımı dirençli bakteri prevalansını artırmakta ve tedavi programlarında sorunlar yaşanmasına neden olmaktadır. Direnç gelişimi nedeniyle hasta ölüm oranları artmaktadır. Çoklu ilaç dirençli ... -
Evaluation of quercetin as a potential β-lactamase CTX-M-15 inhibitor via the molecular docking, dynamics simulations, and MMGBSA
Sarıyer, Emrah; Saral, Ayşegül (Peter Lang AG, 2021)Antimicrobial resistance (AMR) threatens millions of people around the world and has been declared a global risk by the World Economic Forum. One of the important AMR mechanisms in Enterobacteriaceae is the production of ... -
The first study on bacterial flora and biological control agent of the little spruce sawfly, Pristiphora abietina (Christ.) (Hymenoptera: Tenthredinidae)
İskender, Nurcan Albayrak; Örtücü, Serkan; Algur, Ömer Faruk; Aksu, Yaşar; Saral, Ayşegül (ARS DOCENDI, 2017)The aim of this study was to determine the bacterial flora of Pristiphora abietina and to find the performance of the members of this flora as a biocontrol agent for this pest. For this purpose, eleven bacteria were isolated ... -
Investigation of class 1 integrons with antibiotic resistance genes in multidrug-resistant acinetobacter baumannii strains and determination of plant extract effects on multidrug-resistant isolates
Saral, Ayşegül; Cinemre, Sedanur; Okumuş, Funda; Akar, Zeynep; Çiçek, Ayşegül Çopur; Düzgün, Azer Özad (Soc Stiinte Farmaceutice Romania, 2021)This study aimed to investigate the presence of resistance genes in multidrug-resistant A. baumannii isolates as well as to determine the antibacterial activity of selected plant extracts against isolates. 41 strains were ... -
Isolation and characterization of native bacillus thuringiensis from Artvin, Turkey, and screening against hypantaria cunea (lepidoptera)
Albayrak İskender, Nurcan; Saral, Ayşegül (Parlar Scientific Publications, 2017)The soil in different regions may contain new B. thuringiensis species which may be toxic for the harmful insects. For this purpose, 5 native B. thuringiensis strains (Na1, Na2, Na5, Na7, Na25) were isolated from the soil ... -
Isolation, characterization and pathogenicity of fungi from pristiphora abietina (hymenoptera: tenthredinidae)
Albayrak İskender, Nurcan; Örtücü, Serkan; Aksu, Yaşar; Saral, Ayşegül (Parlar Scientific Publications, 2017)This study was conducted to isolate and characterize pathogenic fungi for possible use in biocontrol of P. abietina and to determine their pathogenicity. Eleven fungal isolates were obtained from larvae. Based on traditional ... -
Isolation, identification and characterization of biotechnologically important bacteria from microflora of Dryocosmus kuriphilus Yasumatsu (Hymenoptera: Cynipidae)
Albayrak İskender, Nurcan; Algur, Ömer Faruk; Aksu, Yaşar; Saral, Ayşegül (Taylor & Francis Inc, 2017)The chestnut gall wasp, Dryocosmus kuriphilus Yasumatsu (Hymenoptera: Cynipidae) is one of the most important insect pests of chestnut. The aim of this study was to isolate and characterize bacteria from D. kuriphilus to ... -
Kinetic characterization of GES-22 beta-lactamase harboring the M169L clinical mutation
Saral, Ayşegül; Leonard, David A.; Düzgün, Azer Özad; Çopur Çiçek, Aysegül; June, Cynthia M.; Sandallı, Cemal (Japan Antibiotics Research Assoc, 2016)The class A p-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ... -
Nationwide study of Escherichia coli producing extended-spectrum beta-lactamases TEM, SHV and CTX-M in Turkey
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Düzgün, Azer Özad; Yaşar, Ekrem; Çizmeci, Ekrem; Balcı, Pervin Özlem; Sarı, Fatma; Fırat, Mehmet; Altıntop, Yasemin Ay; Ak, Sibel; Çalışkan, Ahmet; Yıldız, Nazan; Sancaktar, Metin; Budak, Emine Esra; Ertürk, Ayşe; Özgümüş, Osman Birol; Sandallı, Cemal (Springer Nature, 2013)Four hundred and forty extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), ... -
Next-generation sequencing of plasmid carrying blaOXA-48 in Klebsiella pneumoniae from Turkey
Düzgün, Azer Özad; Saral, Ayşegül (Akademia Kiado ZRT, 2019)A carbapenem-resistant Klebsiella pneumoniae strain was isolated in Turkey in 2012 and blaNDM-1 and blaOXA-48 genes were observed in this strain. The aim of this study was to investigate transferability of plasmid bearing ... -
OXA- and GES-type beta-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Iraz, Meryem; Ceylan, Ayşenur; Düzgün, Azer Özad; Peleg, Anton Y.; Sandallı, Cemal (Elsevier SCI LTD, 2014)We determined the antibiotic susceptibility and genetic mechanisms of resistance in clinical strains of Acinetobacter baumannii from Istanbul, Turkey. A total of 101 clinical strains were collected between November 2011 ...
