• The stages of candied chestnut production and the influence of the sorbitol used on their properties 

  Candal, Cihadiye; Mutlu, Ceren; Tontul, S. Arslan; Erbaş, Mustafa (Wageningen Academic Publishers, 2018)

  Chestnut is a healthy and valuable food and it can be consumed in many different forms, such as fresh, boiled, roasted and also candied. The aim of this study was to examine the changes take place in all stages of candied ...

• Effects of high fructose diet on lipid metabolism and the hepatic NF-κB/ SIRT-1 pathway 

  İskender, Hatice; Yenice, Güler; Terim Kapakın, Kübra Asena; Dokumacıoğlu, Eda; Çiğdem, Sevim; Hayırlı, Armağan; Altun, Serdar (Taylor and Francis Ltd., 2021)

  The liver is the primary site for fructose metabolism; therefore, the liver is susceptible to fructose related metabolic disturbances including metabolic insulin dysfunction, dyslipidemia and inflammation. We investigated ...

• A new gluten-free product: Brown rice bulgur, and its physical and chemical properties 

  Candal Uslu, Cihadiye; Mutlu, Ceren; Koç, Adnan; Bilgin, Duygu Gizem; Erbaş, Mustafa (Blackwell Publishing Ltd, 2020)

  In this research, a new alternative food product, defined as brown rice bulgur (BRB), rich in functional components compared to white rice and cooked in a short time compared to brown rice was developed for society especially ...

• The role of rs1799889 genetic variation in type 2 diabetes and diabetic nephropathy risk 

  Bayramoğlu, Ayşegül; Bayramoğlu, Gökhan; Güler, Halil İbrahim (Erciyes Univ Sch Medicine, 2020)

  AI-1 gene 4G/5G and to investigate the role of this polymorphism in T2 DM and DN development. Materials and Methods: The genomic DNA of the 261 individuals was included in this study. The polymerase chain reaction (PCR) ...

• Type 2 diabetes mellitus and diabetic nephropathy with angiotensin ii type 1 receptor gene variants: A case control study in a Turkish population 

  Bayramoğlu, Ayşegül; Bayramoğlu, Gökhan; Güler, Halil İbrahim; Hazar, Güleser (Kuwait Medical Association, 2020)

  Objective: This study was performed to determine the polymorphism frequencies of the Angiotensin II type 1 receptor (AT1) A1166C, and to examine the role of this polymorphism in type-2 diabetes (T2DM) and diabetic nephropathy ...

• The effect of bee pollen on reproductive and biochemical parameters in methotrexate-induced testicular damage in adult rats 

  Saral, Özlem; Dokumacıoğlu, Eda; Saral, Sinan; Sümer, Ayşegül; Bulmuş, Özgür; Özer Kaya, Şeyma; Canpolat, Sinan (De Gruyter Open Ltd, 2020)

  Methotrexate (MTX) is an anticancer drug used in chemotherapy. MTX was known for its toxic effects involving most of the organs including testis. Bee pollen is healthy food for human and has antioxidant effect. We intended ...

• Effects of Interactions among Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia 

  Arpacı, Abdullah; Küçük Urhan, Meral; Bayramoğlu, Ayşegül; Güler, Halil İbrahim; Ecevit, Hasret; Suner, Arif; Karakaş Çelik, Sevim (Univ Press, 2019)

  Introduction: Hypertension (HT) is characterized by high blood pressure. The reninangiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure (BP) regulation by maintaining vascular tone and the water-sodium ...

• Humic acid formation during subcritical water extraction of food by-products using accelerated solvent extractor 

  Özkaynak Kanmaz, Evrim (Institution of Chemical Engineers, 2019)

  In this study, the effect of extraction temperature (180 and 200 degrees C), static extraction time (15, 30 and 45 min) and sample amount (5 and 10 g) on humic acid formation during subcritical water extraction of food ...

• Genetic variations of Renin-angiontensin and Fibrinolytic systems and susceptibility to coronary artery disease: a population genetics perspective 

  Bayramoğlu, Ayşegül; Bayramoğlu, Gökhan; Küçük Urhan, Meral; Güler, Halil İbrahim; Arpacı, Abdullah ([y.y.], 2020)

  BACKGROUND: Genetic predisposition is an important risk factor in coronary artery disease (CAD).This study was conducted to determine the polymorphism frequencies of the plasminogen activator inhibitor-1(PAI-1) gene 4G/5G, ...

• Protective role of Diospyros lotus on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats 

  Saral, Sinan; Özçelik, Eda; Saral, Özlem; Başak, Neşe; Çiftçi, Osman; Aydın, Muhterem (Wiley, 2016)

  The aim of this study was to investigate the protective effect of Diospyros lotus (DL) on cisplatin (CP)-induced testicular damage in male rats. Twenty-eight male rats were randomly divided into four groups: group 1 - ...

• Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension? 

  Bayramoğlu, Ayşegül; Küçük, Meral Urhan; Güler, Halil İbrahim; Abacı, Okay; Küçükkaya, Yunus; Çolak, Ertuğrul (Springer, 2015)

  The current study was conducted to determine whether there is a relation between hypertension and two different polymorphisms, including C1562T of the Matrix metalloproteinase-9 (MMP-9) gene and C677T of the methylenetet ...

• Antimicrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections in Turkey 

  Çopur Çiçek, Ayşegül; Özgümüş, Osman Birol; Saral, Ayşegül; Sandallı, Cemal (Korean Society for Laboratory Medicine, 2014)

  We aimed to observe antimiCrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections. Two hundred sixty-eight E. coli strains were obtained from outpatients with ...

• Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome 

  Uslu, Sema; Özçelik, Eda; Kebapçı, Nur; Temel, Halide Edip; Demirci, Fatih; Ergün, Bülent; Demirüstü, Canan (Springer London LTD, 2016)

  Abstract Background Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on ...

• Chitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen-induced hepatotoxicity 

  Özçelik, Eda; Uslu, Sema; Burukoğlu, Dilek; Musmul, Ahmet (Wolters Kluwer Medknow Publications, 2014)

  Background: Liver diseases have become a major problem of the worldwide. More than 50% of all cases of liver failure can be attributed to drugs. Among these, acetaminophen is the most common cause. Objective: The aim of ...

• Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey 

  Iraz, Meryem; Düzgün, Azer Özad; Çopur Çiçek, Ayşegül; Bonnin, Remy A.; Ceylan, Ayşenur; Saral, Ayşegül; Nordmann, Patrice; Sandallı, Cemal (Elsevier Science INC, 2014)

  Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ...

• Angiotensin II type 1 receptor (AT1) gene A1166C is associated with the risk of hypertension 

  Bayramoğlu, Ayşegül; Kurt, Hülyam; Güneş, Hasan Veysi; Ata, Necmi; Birdane, Alparslan; Dikmen, Miris; Üstüner, Mehmet Cengiz; Çolak, Ertuğrul; Değirmenci, İrfan (Mary Ann Liebert Inc., 2015)

  Aim: This study was performed on primary hypertension patients in a Turkish population to determine the frequency of the A1166C polymorphism in the angiotensin II type 1 receptor (AT1) gene and to examine the role of this ...

• Investigation of relationship between IL-6 gene variants and hypertension in Turkish population 

  Karaman, Esin; Küçük, Meral Urhan; Bayramoğlu, Ayşegül; Göçmen, Semire Uzun; Ercan, Süleyman; Güler, Halil İbrahim; Küçükkaya, Yunus; Erden, Sema (Springer, 2015)

  Hypertension (HT) is a common and life threating health problem worldwide leading to stroke, heart attack and renal failure. It is characterized by elevated blood pressure forced heart load. Human interleukin-6 (IL-6) and ...

• Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats 

  Bayramoğlu, Gökhan; Kurt, Hülyam; Bayramoğlu, Ayşegül; Güneş, Hasan Veysi; Değirmenci, İrfan; Çolak, Suat (Springer, 2015)

  There is little information about the hepatoprotective effects of gallic acid against ischemia-reperfusion (I/R) damage. Animals were subjected to I/R. Gallic acid at doses of 50 and 100 mg/kg body weight (bw) were injected ...

• Comparison of verona integron-borne metallo-β-lactamase (VIM) variants reveals differences in stability and inhibition profiles 

  Makena, Anne; Düzgün, Azer Özad; Brem, Jurgen; McDonough, Michael A.; Rydzik, Anna M.; Abboud, Martine I.; Saral, Ayşegül; Çopur Çiçek, Ayşegül; Sandallı, Cemal; Schofield, Christopher J.; 0000-0002-7757-6812 (Amer Soc Microbiology, 2015)

  Metallo-beta-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. The Verona integron-borne metallo-beta-lactamase ...

• The role of NOD1/CARD4 and NOD2/CARD15 genetic variations in lung cancer risk 

  Özbayer, Cansu; Kurt, Hülyam; Bayramoğlu, Ayşegül; Güneş, Hasan Veysi; Metintaş, Muzaffer; Değirmenci, İrfan; Öner, Kevser Setenay (Springer Basel Ag, 2015)

  Background and aim NOD1/CARD4 and NOD2/CARD15 are members of the Nod-like receptor (NLR) family, and they contain a caspase recruitment domain (CARD). NLRs are located in the cytosol where they bind bacterial and viral ...

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