Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NF kappa B/SIRT1 pathway and mitigating oxidative stress
Kapakın, Kübra Asena Terim
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CitationIskender, H., Dokumacioglu, E., Yenice, G., Hayirli, A., Sevim, C., Dokumacioglu, A., & Terim Kapakin, K. A.. (2020). Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NFκB/SIRT1 pathway and mitigating oxidative stress. Archives of Physiology and Biochemistry. 126(1), 89-93. https://doi.org/10.1080/13813455.2018.1493609
This study was conducted to determine the effect of astaxanthin (ASX) treatment on alleviation ofrenal damage in high fructose induced nephrotoxicity in rats. Treatments were arranged in a 2 2 fac-torial fashion: administrations of fructose (30%, via drinking water) and ASX (1 mg/kg/day, within0.2ml olive oil) for 8 weeks. Data were analyzed by two-way ANOVA. The ASX treatment decreasedserum urea (p<.01) and blood urea–N concentrations (p<.02) at a lower extent in rats receiving fruc-tose than those not receiving fructose. Moreover, the ASX treatment reversed the increases in malon-dialdehyde (MDA) (p<.0001) and nuclear factor kappa B (NF-jB) (p<.0003) levels and the decreasesin superoxide dismutase (SOD) activity (p<.0001) and sirtuin-1 (SIRT1) level (p<.0004), in the kidneyupon high fructose consumption. The data suggest that ASX supplementation alleviates renal damageinduced by high fructose consumption through modulating NF-jB/SIRT1 pathway and mitigating oxi-dative stress.