Show simple item record

dc.contributor.authorŞahin, A.
dc.contributor.authorİskender, Hatice
dc.contributor.authorKapakin, Terim K. A.
dc.contributor.authorAltınkaynak, Konca
dc.contributor.authorHayırlı, Armağan
dc.contributor.authorGönültaş, Aylin
dc.contributor.authorKaynar, Oezguer
dc.date.accessioned2020-04-21T08:02:00Z
dc.date.available2020-04-21T08:02:00Z
dc.date.issued2016en_US
dc.identifier.citationSahin, A., Iskender, H., Terim Kapakin, K. A., Altinkaynak, K., Hayirli, A., Gonultas, A., & Kaynar, O. (2016). The effect of humic acid substances on the thyroid function and structure in lead poisoning. Revista Brasileira de Ciencia Avicola, 18(4), 649–654. https://doi.org/10.1590/1806-9061-2016-0299en_US
dc.identifier.urihttps://hdl.handle.net/11494/2039
dc.description.abstractLead (Pb) is a heavy metal, which adversely affects thyroid gland function and structure. Due to its high molecular weight and abundant functional groups, humic acid substances (HAS) can form chelates with heavy metals. The experiment was conducted to evaluate the prophylactic effect of HAS on thyroid hormone levels and histopathological lesions of laying hens exposed to lead (Pb) poisoning. After a week of adaptation, 192 Lohmann White laying hens (25 weeks of age) were fed one of four diets: a basal diet (BD) or the BD with HAS (0.15%), with Pb (0.3 g/kg), or with both. Experimental groups were replicated in 12 cages, with four hens each. Pb poisoning did not alter triiodothyronine (FT3; 3.22 ± 0.20 ng/dL) or thyroxine (FT4; 0.71 ± 0.08 ng/dL) concentrations, but caused a 167% increase in thyroid stimulating hormone (TSH) concentration. HAS supplementation returned the high TSH levels of hens exposed to Pb poisoning to normal values. Degenerative changes in the epithelial cells of the thyroid gland of the hens exposed to Pb poisoning were evidenced. Connective tissue cells in the interfollicular area and total amount of colloids with partially atrophic follicles were observed. These histopathological findings were less severe when HAS was added to the diet. In conclusion, HAS alleviates the effects of Pb poisoning on thyroid gland function and structure, possibly preventing its internalization by the tissue by forming chelates and exerting anti-inflammatory effects.en_US
dc.language.isoengen_US
dc.publisherFACTA-FUNDACIO ARNCO CIENCIA TECNOLOGIA AVICOLASen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLead poisoningen_US
dc.subjecthumic acid substancesen_US
dc.subjectThyroid glanden_US
dc.subjectChickenen_US
dc.titleThe effect of humic acid substances on the thyroid function and structure in lead poisoningen_US
dc.typearticleen_US
dc.relation.journalBrazilian Journal Of Poultry Scienceen_US
dc.departmentAÇÜ, Rektörlüken_US
dc.identifier.volume18en_US
dc.identifier.issue4en_US
dc.identifier.startpage649en_US
dc.identifier.endpage653en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1590/1806-9061-2016-0299en_US
dc.contributor.institutionauthor[0-Belirlenecek]en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record