dc.contributor.author | Dokumacıoğlu, Eda | |
dc.contributor.author | Demiray, Özay | |
dc.contributor.author | Dokumacıoğlu, Ali | |
dc.contributor.author | Şahin, Arzu | |
dc.contributor.author | Şen, Tuğba Mazlum | |
dc.contributor.author | Cankaya, Mazlum | |
dc.date.accessioned | 2020-06-29T11:55:07Z | |
dc.date.available | 2020-06-29T11:55:07Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Dokumacıoğlu, E., Demiray, O., Dokumacıoğlu, A., Şahin, A., Şen, T. M., & Cankaya, S. (2018). Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder. Investigative and Clinical Urology, 59(4), 252-256. | en_US |
dc.identifier.uri | https://hdl.handle.net/11494/2132 | |
dc.description.abstract | Purpose: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation.
Materials and Methods: A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease. Levels of MDA and 8-OHdG were measured in 24-hour urine samples for all subjects.
Results: Urinary levels of MDA and 8-OHdG were significantly higher in the OAB group than in the control group (p<0.001). A significant positive correlation (p<0.001) was found between the measurements of 8-OHdG and MDA.
Conclusions: Oxidative stress may be important in the pathophysiology of OAB, because levels of 8-OHdG and MDA are increased. Increased levels of 8-OHdG may be due to damaged nuclear and mitochondrial DNA as a result of oxidative attacks caused by free radicals. Nevertheless, further randomized and prospective studies with larger patient populations are needed | en_US |
dc.description.sponsorship | This work was supported by Coordinator of Scientific Research Projects (2015.M80.02.04) at Artvin Coruh University. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Korean Urological Assoc | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
dc.subject | Lipid peroxidation | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Urinary bladder | en_US |
dc.subject | overactive | en_US |
dc.subject | 8OHdG | en_US |
dc.title | Measuring urinary 8-hydroxy-2'-deoxyguanosine and malondialdehyde levels in women with overactive bladder | en_US |
dc.type | article | en_US |
dc.relation.journal | Investigative and Clinical Urology | en_US |
dc.department | AÇÜ, Sağlık Bilimleri Fakültesi | en_US |
dc.authorid | 0000-0002-2223-1331 | en_US |
dc.identifier.volume | 59 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 252 | en_US |
dc.identifier.endpage | 256 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.4111/icu.2018.59.4.252 | en_US |
dc.contributor.institutionauthor | Dokumacıoğlu, Eda | en_US |