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dc.contributor.authorDüzgün, Özer Özad
dc.contributor.authorOkumuş, Funda
dc.contributor.authorSaral, Ayşegül
dc.contributor.authorÇopur Çiçek, Ayşegül
dc.contributor.authorCinemre, Sedanur
dc.date.accessioned2020-10-28T07:17:16Z
dc.date.available2020-10-28T07:17:16Z
dc.date.issued2019en_US
dc.identifier.citationDüzgün, A. Ö., Okumuş, F., Saral, A., Çiçek, A. Ç., & Cinemre, S. (2019). Determination of antibiotic resistance genes and virulence factors in Escherichia coli isolated from Turkish patients with urinary tract infection. Revista da Sociedade Brasileira de Medicina Tropical, 52. Doi: 10.1590/0037-8682-0499-2018en_US
dc.identifier.urihttps://hdl.handle.net/11494/2390
dc.description.abstractIntroduction: Escherichia coli ranks among the most common sources of urinary tract infections (UTI). Methods: Between November 2015 and August 2016, 90 isolates of E. coli were isolated from patients at Rize Education and Research Hospital in Turkey. Antibiotic susceptibility was determined for all isolates using the Kirby–Bauer disk diffusion method. These E. coli isolates were also screened for virulence genes, β-lactamase coding genes, quinolone resistance genes, and class 1 integrons by PCR. Results: With respect to the antibiotic resistance profile, imipenem and meropenem were effective against 98% and 90% of isolates, respectively. A high percentage of the isolates showed resistance against β lactam/β lactamase inhibitor combinations, quinolones, and cephalosporins. PCR results revealed that 63% (57/90) of the strains carried class 1 integrons. In addition, a high predominance of extended-spectrum β-lactamases (ESBLs) was observed. The qnrA, qnrB, and qnrS genes were found in 24 (26.6%), 6 (6.6%), and 3 (3.3%), isolates, respectively. The most common virulence gene was fim (82.2%).The afa, hly, and cnf1 genes were detected in 16.6%, 16.6%, and 3.3% of isolates, respectively. Moreover, we observed eleven different virulence patterns in the 90 E. coli isolates. The most prevalent pattern was fım, while hly-fım, afa-aer-cnf-fım, aer-cnf, afa-aer, and afacnf-fım patterns were less common. Conclusions: Most of the E. coli virulence genes investigated in this study were observed in E. coli isolates from UTI patients. Virulence genes are very important for the establishment and maintenance of infection.en_US
dc.language.isoengen_US
dc.publisherSoc Brasileira Medicina Tropicalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectQuinolonesen_US
dc.subjectVirulence genesen_US
dc.subjectUTIen_US
dc.titleDetermination of antibiotic resistance genes and virulence factors in Escherichia coli isolated from Turkish patients with urinary tract infectionen_US
dc.typearticleen_US
dc.relation.journalRevista da Sociedade Brasileira de Medicina Tropicalen_US
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.authorid0000-0002-6301-611Xen_US
dc.authorid0000-0002-7757-6812en_US
dc.identifier.volume52en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1590/0037-8682-0499-2018en_US
dc.contributor.institutionauthorSaral, Ayşegülen_US


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