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Secondary sulfonamides as effective lactoperoxidase inhibitors

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info:eu-repo/semantics/openAccess

Date

2017

Author

Köksal, Zeynep
Kalın, Ramazan
Camadan, Yasemin
Usanmaz, Hande
Almaz, Züleyha
Gülçin, İlhami
Ğökçe, Taner
Gören, Ahmet Ceyhan
Özdemir, Hasan

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Köksal, Z., Kalın, R., Camadan, Y., Usanmaz, H., Almaz, Z., Gülçin, I., ... & Özdemir, H. (2017). Secondary sulfonamides as effective lactoperoxidase inhibitors. Molecules, 22(6), 793. Doi: 10.3390/molecules22060793

Abstract

Secondary sulfonamides (4a–8h) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C.1.11.1.7), as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study, the in vitro inhibitory effects of some secondary sulfonamide derivatives (4a–8h) were examined against LPO. The obtained results reveal that secondary sulfonamide derivatives (4a–8h) are effective LPO inhibitors. The Ki values of secondary sulfonamide derivatives (4a–8h) were found in the range of 1.096 × 10−3 to 1203.83 µM against LPO. However, the most effective inhibition was found for N-(sulfathiazole)-3,4,5-triacetoxybenzamide (6a), with Ki values of 1.096 × 10−3 ± 0.471 × 10−3 µM as non-competitive inhibition.

Source

Molecules

Volume

22

Issue

6

URI

https://hdl.handle.net/11494/2391

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  • PubMed İndeksli Yayınlar Koleksiyonu [185]
  • Sağlık Hizmetleri Meslek Yüksekokulu Yayın Koleksiyonu [61]
  • Scopus İndeksli Yayınlar Koleksiyonu [879]
  • WoS İndeksli Yayınlar Koleksiyonu [1133]



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