Basit öğe kaydını göster

dc.contributor.authorBakır, Murat
dc.contributor.authorGeyikoğlu, Fatime
dc.contributor.authorÇolak, Suat
dc.contributor.authorTürkez, Hasan
dc.contributor.authorBakır, Tülay Özhan
dc.contributor.authorHosseinigouzdagani, Mirkhalil
dc.date.accessioned2020-11-06T11:46:48Z
dc.date.available2020-11-06T11:46:48Z
dc.date.issued2016en_US
dc.identifier.citationBakır, M., Geyikoğlu, F., Çolak, S., Türkez, H., Bakır, T. O., & Hosseinigouzdagani, M. (2016). The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response. Cytotechnology, 68(4), 1131-1146.en_US
dc.identifier.urihttps://hdl.handle.net/11494/2424
dc.description.abstractAcute pancreatitis (AP) may cause significant persistent multi-organ dysfunction. Carvacrol (CAR) possesses a variety of biological and pharmacological properties. The aim of the present study was to analyze the hepatic protection of CAR on AP induced by cerulein and to explore the underlying mechanism using in vivo studies. The rats were randomized into groups to receive (1) no therapy; (2) 50 A mu g/kg cerulein at 1-h intervals by four intraperitoneal injection (i.p.); (3) 50, 100 and 200 mg/kg CAR by one i.p.; and (4) cerulein + CAR after 2 h of cerulein injection. 12 h later, serum was provided to assess the blood AST, ALT and LDH values. Also, liver tissues were obtained for histological and biochemical measurements. Liver oxidative stress markers were evaluated by changes in the amount of lipid peroxides measured as MDA and changes in tissue antioxidant enzyme levels, SOD, CAT and GSH-Px. Histopathological examination was performed using scoring systems. Oxidative damage to DNA was quantitated in studied tissues of experimental animals by measuring the increase in 8-hydroxydeoxyguanosine (8-OHdG) formations. We found that the increasing doses of CAR decreased pancreatitis-induced MDA and 8-OH-dG levels. Moreover, the liver SOD, CAT and GSH-Px activities in the AP + CAR group were higher than that of the rats in the AP group. In the treatment groups, AST, ALT and LDH were reduced. Besides, necrosis, coagulation and inflammation in the liver were alleviated (p < 0.05). We suggest that CAR could be a safe and potent new drug candidate for treating AP through its antioxidative mechanism of action for the treatment of a wide range of disorders related to hepatic dysfunction.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental acute pancreatitisen_US
dc.subjectLiverdamageen_US
dc.subjectCarvacrolen_US
dc.subjectAntioxidant responseen_US
dc.subjectOxidative DNA damageen_US
dc.subjectHistopathologyen_US
dc.titleThe carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant responseen_US
dc.typearticleen_US
dc.relation.journalCytotechnologyen_US
dc.departmentAÇÜ, Rektörlüken_US
dc.authorid0000-0001-8320-3038en_US
dc.identifier.volume68en_US
dc.identifier.issue4en_US
dc.identifier.startpage1131en_US
dc.identifier.endpage1146en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10616-015-9871-zen_US
dc.contributor.institutionauthorÇolak, Suaten_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster