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Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats

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info:eu-repo/semantics/openAccess

Date

2014

Author

Bayramoğlu, Gökhan
Şentürk, Hakan
Bayramoğlu, Ayşegül
Uyanoğlu, Mustafa
Çolak, Suat
Özmen, Ayşe
Kolankaya, Durdane

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Bayramoğlu, G., Şentürk, H., Bayramoğlu, A., Uyanoğlu, M., Çolak, S., Özmen, A., & Kolankaya, D. (2014). Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats. Cytotechnology, 66(2), 251-257.

Abstract

Little is known about the protective effects of carvacrol on the symptoms of streptozotocin induced diabetes in rats. Hence, this present study was designed to evaluate the protective effect of the strong antioxidant, carvacrol, on the symptoms of streptozotocin induced diabetes in rats. Carvacrol at the doses of 25 and 50 mg/kg body weight were orally administered to diabetic rats for a period of 7 days after the onset of diabetes. Food-water intake and body weight changes were daily recorded. Biochemical parameters such as serum glucose, insulin, total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase were measured. Although treatment of diabetic rats with oral administration of carvacrol resulted in a slight reduction in serum glucose level and significant reduction in serum total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase in comparison with diabetic control rats, there were no significant differences in serum insulin levels, foodwater intake values and body weight changes. Despite the inadequacy of carvacrol on diabetes treatments, it was determined to have at least a partially protective role on liver enzymes.

Source

Cytotechnology

Volume

66

Issue

2

URI

https://hdl.handle.net/11494/2432

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  • Artvin MYO Koleksiyonu - Makaleler [74]
  • Beslenme ve Diyetetik Bölümü Koleksiyonu - Makaleler [54]
  • PubMed İndeksli Yayınlar Koleksiyonu [149]
  • Scopus İndeksli Yayınlar Koleksiyonu [525]
  • WoS İndeksli Yayınlar Koleksiyonu [685]



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