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Angiotensin II type 1 receptor (AT1) gene A1166C is associated with the risk of hypertension

Access

info:eu-repo/semantics/closedAccess

Date

2015

Author

Bayramoğlu, Ayşegül
Kurt, Hülyam
Güneş, Hasan Veysi
Ata, Necmi
Birdane, Alparslan
Dikmen, Miris
Üstüner, Mehmet Cengiz
Çolak, Ertuğrul
Değirmenci, İrfan

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Citation

Bayramoğlu, A., Kurt, H., Güneş, H. V., Ata, N., Birdane, A., Dikmen, M., ... & Degirmenci, I. (2015). Angiotensin II type 1 receptor (AT1) gene A1166C is associated with the risk of hypertension. Genetic Testing and Molecular Biomarkers, 19(1), 14-17.

Abstract

Aim: This study was performed on primary hypertension patients in a Turkish population to determine the frequency of the A1166C polymorphism in the angiotensin II type 1 receptor (AT1) gene and to examine the role of this polymorphism in hypertension development. Materials and Methods: In this study, 250 genomic DNA samples were collected (from 142 hypertension patients and 108 healthy subjects), randomized, and analyzed. Genomic DNA was prepared from peripheral blood using the salt extraction method. The presence of the A1166C polymorphism in the AT1 gene was determined using the polymerase chain reaction (PCR)-restriction fragment length polymorphism method. PCR products were separated by 2% agarose gel electrophoresis and visualized by a charge-coupled device camera. Results: Genotype distribution and allele frequency A1166C genotype frequency was determined as AA 96.3% and AC 3.7% for controls and as AA 86.6% and AC 13.4% for patients. A statistically significant difference was found between the control group and patients in terms of genotype and allele frequency. Conclusion: Our results suggest that an interaction exists between the AT1 gene polymorphism and hypertension in the Turkish population.

Source

Genetic Testing and Molecular Biomarkers

Volume

19

Issue

1

URI

https://hdl.handle.net/11494/2447

Collections

  • Beslenme ve Diyetetik Bölümü Koleksiyonu - Makaleler [56]
  • PubMed İndeksli Yayınlar Koleksiyonu [149]
  • Scopus İndeksli Yayınlar Koleksiyonu [536]
  • WoS İndeksli Yayınlar Koleksiyonu [700]



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