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Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome

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Date

2016

Author

Uslu, Sema
Özçelik, Eda
Kebapçı, Nur
Temel, Halide Edip
Demirci, Fatih
Ergün, Bülent
Demirüstü, Canan

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Uslu, S., Özçelik, E., Kebapçı, N., Temel, H. E., Demirci, F., Ergün, B., & Demirüstü, C. (2016). Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome. Irish Journal of Medical Science. 185(1), 259-263.

Abstract

Abstract Background Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome (MetS). Methods Serum arginase activity, and nitrite and uric acid levels were measured in 48 women with MetS and in 20 healthy controls. The correlation of these parameters with components of MetS was also evaluated. Results Our data show statistically higher arginase activity and uric acid levels but lower nitrite levels in women with MetS compared to controls. Serum uric acid levels were negatively correlated with HDL cholesterol, nitrite levels and positively with Body Mass Index, waist to hip ratio, triglyceride and total cholesterol levels, systolic blood pressure, Homeostasis Model Assessment-Insulin Resistance-Index, serum arginase activity, and LDL-cholesterol levels in women with MetS. Conclusion Results of the present study suggest that serum uric acid levels may contribute to the pathogenesis of MetS through a process mediated by arginase pathway, and serum arginase activity and nitrite and uric acid levels can be used as indicators of CVD in women with MetS.

Source

Irish Journal of Medical Science.

Volume

185

Issue

1

URI

https://hdl.handle.net/11494/2452

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  • Beslenme ve Diyetetik Bölümü Yayın Koleksiyonu [96]
  • PubMed İndeksli Yayınlar Koleksiyonu [191]
  • Scopus İndeksli Yayınlar Koleksiyonu [927]
  • WoS İndeksli Yayınlar Koleksiyonu [1182]



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