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Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey

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info:eu-repo/semantics/closedAccess

Date

2014

Author

Iraz, Meryem
Düzgün, Azer Özad
Çopur Çiçek, Ayşegül
Bonnin, Remy A.
Ceylan, Ayşenur
Saral, Ayşegül
Nordmann, Patrice
Sandallı, Cemal

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Citation

Iraz, M., Düzgün, A. O., Çiçek, A. C., Bonnin, R. A., Ceylan, A., Saral, A., ... & Sandallı, C. (2014). Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey. Diagnostic Microbiology and Infectious Disease, 78(3), 292-294.

Abstract

Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = I). PCR and DNA sequence analysis revealed that 1 strain possessed the bla(GES-5) and another carried a novel bla(VIM) variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey. (C) 2014 Elsevier Inc. All rights reserved.

Source

Diagnostic Microbiology and Infectious Disease

Volume

78

Issue

3

URI

https://hdl.handle.net/11494/2456

Collections

  • Beslenme ve Diyetetik Bölümü Koleksiyonu - Makaleler [54]
  • PubMed İndeksli Yayınlar Koleksiyonu [149]
  • Scopus İndeksli Yayınlar Koleksiyonu [525]
  • WoS İndeksli Yayınlar Koleksiyonu [685]



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