• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace@Artvin
  • Rektörlüğe Bağlı Bölümler
  • Rektörlük
  • View Item
  •   DSpace@Artvin
  • Rektörlüğe Bağlı Bölümler
  • Rektörlük
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Effects of lichen extracts on haematological parameters of rats with experimental insulin-dependent diabetes mellitus

Access

info:eu-repo/semantics/closedAccess

Date

2014

Author

Çolak, Suat
Geyikoğlu, Fatime
Aslan, Ali
Deniz, Gülşah Yıldız

Metadata

Show full item record

Citation

Çolak, S., Geyikoğlu, F., Aslan, A., & Deniz, G. Y. (2014). Effects of lichen extracts on haematological parameters of rats with experimental insulin-dependent diabetes mellitus. Toxicology and Industrial Health, 30(10), 878-887.

Abstract

The prevalence of diabetes mellitus in the world is steadily increasing. Oxidative stress contributes to the development of diabetic complications, including diabetic haematological changes. Lichens are used as food supplements and are also used as possible natural antioxidant, antimicrobial and anticancer agents. We hypothesized that antioxidant activity of lichens may decrease hyperglycaemia-induced oxidative stress and prevent the development of diabetic complications, including abnormality in haematological condition. Therefore, the effects of Cetraria islandica water extract (CIWE) and Pseudevernia furfuracea water extract (PFWE) on the haematological parameters of rats with type 1 DM were investigated for the first time in the present study. Control Sprague-Dawley or streptozotocin (STZ)-induced diabetic rats were either untreated or treated with water lichen extracts (5-500mg/kg body weight (bw)/day) for 2weeks, starting at 72h after STZ injection. On day 14, animals were anaesthetized and haematological and metabolic parameters were determined between control and experimental groups. In addition, the total oxidative stress (TOS), a specific indicator of oxidative stress, and the total antioxidant capacity (TAC) were measured by biochemical studies. In diabetic rats, CIWE of 250-500mg/kg bw dose showed more prominent results when compared with doses of PFWE for TAC. The results obtained in the present study suggested that the antioxidant activities of lichens might be the possible reason behind the observed antihaematological status. However, the protective effect of lichen extracts were inadequate on diabetes-induced microcytic hypochromic anaemia. In addition, the extracts have no effect on metabolic complications. Our experimental data showed that high doses of CIWE and PFWE alone have no detrimental effect on blood cells and TOS status of plasma. Hence, they are safe and suitable for different administration routes.

Source

Toxicology and Industrial Health

Volume

30

Issue

10

URI

https://hdl.handle.net/11494/2460

Collections

  • PubMed İndeksli Yayınlar Koleksiyonu [149]
  • Rektörlük [10]
  • Scopus İndeksli Yayınlar Koleksiyonu [525]
  • WoS İndeksli Yayınlar Koleksiyonu [685]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Policy | Guide | Contact |
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess TypeThis CollectionBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess Type

My Account

LoginRegister

Statistics

View Google Analytics Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


|| Policy || Guide || Library || Artvin Çoruh University || OAI-PMH ||

Artvin Çoruh University, Artvin, Turkey
If you find any errors in content, please contact:

Creative Commons License
Artvin Çoruh University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@Artvin:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.