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dc.contributor.authorÇolak, Suat
dc.contributor.authorGeyikoğlu, Fatime
dc.contributor.authorAslan, Ali
dc.contributor.authorDeniz, Gülşah Yıldız
dc.date.accessioned2020-11-16T07:41:04Z
dc.date.available2020-11-16T07:41:04Z
dc.date.issued2014en_US
dc.identifier.citationÇolak, S., Geyikoğlu, F., Aslan, A., & Deniz, G. Y. (2014). Effects of lichen extracts on haematological parameters of rats with experimental insulin-dependent diabetes mellitus. Toxicology and Industrial Health, 30(10), 878-887.en_US
dc.identifier.urihttps://hdl.handle.net/11494/2460
dc.description.abstractThe prevalence of diabetes mellitus in the world is steadily increasing. Oxidative stress contributes to the development of diabetic complications, including diabetic haematological changes. Lichens are used as food supplements and are also used as possible natural antioxidant, antimicrobial and anticancer agents. We hypothesized that antioxidant activity of lichens may decrease hyperglycaemia-induced oxidative stress and prevent the development of diabetic complications, including abnormality in haematological condition. Therefore, the effects of Cetraria islandica water extract (CIWE) and Pseudevernia furfuracea water extract (PFWE) on the haematological parameters of rats with type 1 DM were investigated for the first time in the present study. Control Sprague-Dawley or streptozotocin (STZ)-induced diabetic rats were either untreated or treated with water lichen extracts (5-500mg/kg body weight (bw)/day) for 2weeks, starting at 72h after STZ injection. On day 14, animals were anaesthetized and haematological and metabolic parameters were determined between control and experimental groups. In addition, the total oxidative stress (TOS), a specific indicator of oxidative stress, and the total antioxidant capacity (TAC) were measured by biochemical studies. In diabetic rats, CIWE of 250-500mg/kg bw dose showed more prominent results when compared with doses of PFWE for TAC. The results obtained in the present study suggested that the antioxidant activities of lichens might be the possible reason behind the observed antihaematological status. However, the protective effect of lichen extracts were inadequate on diabetes-induced microcytic hypochromic anaemia. In addition, the extracts have no effect on metabolic complications. Our experimental data showed that high doses of CIWE and PFWE alone have no detrimental effect on blood cells and TOS status of plasma. Hence, they are safe and suitable for different administration routes.en_US
dc.description.sponsorshipThis investigation was supported by Ataturk University (grant number: 2010/273).en_US
dc.language.isoengen_US
dc.publisherSage Publicationsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCetraria islandicaen_US
dc.subjectPseudevernia furfuraceaen_US
dc.subjectType 1 diabetesen_US
dc.subjectHaematological parameteren_US
dc.subjectOxidative stressen_US
dc.titleEffects of lichen extracts on haematological parameters of rats with experimental insulin-dependent diabetes mellitusen_US
dc.typearticleen_US
dc.relation.journalToxicology and Industrial Healthen_US
dc.departmentAÇÜ, Rektörlüken_US
dc.authoridTR26723en_US
dc.identifier.volume30en_US
dc.identifier.issue10en_US
dc.identifier.startpage878en_US
dc.identifier.endpage887en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1177/0748233712466130en_US
dc.contributor.institutionauthorÇolak, Suaten_US


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