Basit öğe kaydını göster

dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorKüçük Urhan, Meral
dc.contributor.authorGüler, Halil İbrahim
dc.contributor.authorArpacı, Abdullah
dc.date.accessioned2020-11-17T07:38:11Z
dc.date.available2020-11-17T07:38:11Z
dc.date.issued2020en_US
dc.identifier.citationBayramoğlu, A., Bayramoğlu, G., Güler, H. İ., & Arpacı, A. (2020). Genetic variations of Renin-angiontensin and Fibrinolytic systems and susceptibility to coronary artery disease: a population genetics perspective. Minerva Cardioangiologica.en_US
dc.identifier.urihttps://hdl.handle.net/11494/2469
dc.description.abstractBACKGROUND: Genetic predisposition is an important risk factor in coronary artery disease (CAD).This study was conducted to determine the polymorphism frequencies of the plasminogen activator inhibitor-1(PAI-1) gene 4G/5G, Angiotensin-converting enzyme (ACE) gene I/D,and Angiotensin II type 1 receptor (AT1) gene A1166C genotypes and to examine the role of these polymorphisms in CAD. METHODS: Genomic DNAs obtained from 260 subjects(130 CAD patients and 130 control) were used in the study. ACE I/D and PAI-1 4G/5G polymorphism genotypes were determined using polymerase chain reaction (PCR) and electrophoresis. AT-1 A1166C polymorphism was determined using the PCR, restriction fragment length polymorphism (RFLP) and electrophoresis. The products amplified from AT1 gene by PCR were cut with HindIII restriction endonuclease and then analyzed by 2% agarose gel electrophoresis. The results were statistically analyzed with the chi-square test, Mann-Whitney U test, and independent two-sample t-test. RESULTS: Allele frequencies showed statistically significant differences between the patient and control groups. There was no statistically significant difference in ACEI/D genotype frequencies between the twogroups. Likewise, no statistically significant difference was found in the AT1 A1166C genotype frequencies; however, a statistically significant difference was found in allele frequencies.The PAI-1 4G/5G genotype frequency was significantly higher in the patient group. CONCLUSIONS: While there is a relationship between of PAI-1 gene 4G/5G polymorphism and CAD, ACE gene I/D and AT1 gene A1166C polymorphisms are not related. PAI-1 gene homozygous genotypes may be considered as a prognostic marker for CAD patients.en_US
dc.language.isoengen_US
dc.publisher[y.y.]en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectCADen_US
dc.subjectACE I/Den_US
dc.subjectAT1 A1166C polymorphismen_US
dc.subjectPAI-1en_US
dc.subjectRs1799889en_US
dc.titleGenetic variations of Renin-angiontensin and Fibrinolytic systems and susceptibility to coronary artery disease: a population genetics perspectiveen_US
dc.typearticleen_US
dc.relation.journalMinerva Cardioangiologica.en_US
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.authorid0000-0001-8567-807Xen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23736/S0026-4725.20.05212-3en_US
dc.contributor.institutionauthorBayramoğlu, Ayşegülen_US
dc.contributor.institutionauthorBayramoğlu, Gökhan


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster