Effects of Interactions among Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessTarih
2019Yazar
Arpacı, AbdullahKüçük Urhan, Meral
Bayramoğlu, Ayşegül
Güler, Halil İbrahim
Ecevit, Hasret
Suner, Arif
Karakaş Çelik, Sevim
Üst veri
Tüm öğe kaydını gösterKünye
Arpacı, A., Urhan Küçük, M., Bayramoğlu, A., Güler, H. İ., Ecevit, H., Suner, A., & Karakaş Çelik, S. (2019). Effects of Interactions among Gene Polymorphisms of the Renin–Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia. Revista Romana de Medicina de Laborator, 27(2), 159-168.Özet
Introduction: Hypertension (HT) is characterized by high blood pressure. The reninangiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure (BP) regulation by maintaining vascular tone and the water-sodium balance. We aimed to investigate whether there is any relation between AGT (M235T), ACE (I/D), and AGTR1
(A1166C) genetic polymorphisms and hypertension among Turkish people from Southeast Anatolia.
Method and Results: A total of 210 individuals, consisting of 102 healthy controls and 108 patients with essential
hypertension admitted to the Cardiology Department of the Adıyaman University Research and Application Hospital were included the study. DNA isolation was performed from the blood samples via commercial kit. Genotype determination was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) technique. Statistically significant differences were found between the control and patient groups in terms of
genotype distribution and allelic frequencies of ACE I/D polymorphisms. Significant differences were found in the
frequencies of ICM, DCM, DCT, DAT between the patient and control groups.
Conclusions: In this study, we found a significant association of ACE I/D polymorphism with HT, and we showed
that the I allele can increase the risk of HT in Turkish people from Southeast Anatolia. Although we did not find any
association between independent AGT M235T and AGT1R A1166C polymorphisms and HT, we observed that the
DCM, DCT, and DAT haplotypes of ACE/AGT1R/AGT polymorphisms reduced the risk of hypertension, while the
ICM haplotype increased it.