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dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorGüler, Halil İbrahim
dc.contributor.authorHazar, Güleser
dc.date.accessioned2021-01-19T12:28:01Z
dc.date.available2021-01-19T12:28:01Z
dc.date.issued2020en_US
dc.identifier.citationBayrampğlu, A., Bayramoğlu, G., Güler, H. İ., Hazar, G., (2020). Type 2 diabetes mellitus and diabetic nephropathy with angiotensin ii type 1 receptor gene variants: A case control study in a Turkish population. Kuwait Medical Journal.52(4), 426-430.en_US
dc.identifier.urihttps://hdl.handle.net/11494/2560
dc.descriptionThis study was supported by a grant of the Research Foundation of University of Artvin Coruh, Turkey (Grant No. 2011.M80.02.01). This work was supported by Dr. Umut Tendik (Internal Medicine specialist), providing us with samples and diagnoses of T2DM and DN patients and we express our gratitude to him.en_US
dc.description.abstractObjective: This study was performed to determine the polymorphism frequencies of the Angiotensin II type 1 receptor (AT1) A1166C, and to examine the role of this polymorphism in type-2 diabetes (T2DM) and diabetic nephropathy (DN) development. Design: This is a research study. Setting: Clinic for Internal Medicine, Artvin State Hospital, Turkey Subjects: The study consisted of 259 (135 T2DM and DN + 124 controls) persons referred to the Clinic for Internal Medicine, Artvin State Hospital. Intervention: This study used peripheral blood samples. Main outcome measures: Two hundred and fifty-nine genomic DNAs were analyzed. AT1 gene A1166C polymorphisms were determined using polymerase chain reaction (PCR), restriction fragment length polymorphism and electrophoresis. PCR products were digested with restriction enzyme HindIII and were analyzed in 2% agarose gel electrophoresis. Results: The frequencies of A1166C genotypes were found to be 32.3% AC and 67.7% CC in controls and 73% AC and 27% CC in total patient group. Statistically, it was found that the AT1 gene A1166C polymorphism genotype was significantly different between the control group and the total patient’s group. Conclusions: As a result, we can say that there is an interaction between the AT1 gene A1166C polymorphism with T2DM and DN.en_US
dc.language.isoturen_US
dc.publisherKuwait Medical Associationen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectA1166C polymorphismen_US
dc.subjectAT1 geneen_US
dc.subjectDiabetic nephropathyen_US
dc.subjectType-2 diabetesen_US
dc.titleType 2 diabetes mellitus and diabetic nephropathy with angiotensin ii type 1 receptor gene variants: A case control study in a Turkish populationen_US
dc.typearticleen_US
dc.relation.journalKuwait Medical Journalen_US
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.authorid0000-0001-8567-807Xen_US
dc.identifier.volume52en_US
dc.identifier.issue4en_US
dc.identifier.startpage426en_US
dc.identifier.endpage430en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorBayramoğlu, Ayşegülen_US
dc.contributor.institutionauthorBayramoğlu, Gökhan
dc.contributor.institutionauthorHazar, Güleser


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