The role of rs1799889 genetic variation in type 2 diabetes and diabetic nephropathy risk
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CitationBayramoğlu, A., Bayramoğlu, G., & Güler, H. İ. (2020). The Role of rs1799889 Genetic Variation in Type 2 Diabetes and Diabetic Nephropathy Risk. Erciyes Medical Journal/Erciyes Tip Dergisi, 42(4), 441-446.
AI-1 gene 4G/5G and to investigate the role of this polymorphism in T2 DM and DN development. Materials and Methods: The genomic DNA of the 261 individuals was included in this study. The polymerase chain reaction (PCR) method with 4G and 5G allele-particular primers was used to identify the polymorphism of PAI-1 4G/5G. The PCR products were evaluated using a CCD camera after 2% agarose gel electrophoresis. Results: Although the frequencies of the gene genotypes differed statistically significant between 80 patients and 51 patients with and without DN, respectively, and the control group, no statistically significant difference was detected between those with and without DN. The 5G/5G genotype was found to be significantly higher in the patient group. Conclusion: The findings suggest that there is a significant correlation between variants of the PAI-1 gene and the risk for T2 DM formation.
SourceErciyes Medical Journal/ Erciyes Tip Dergisi
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