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dc.contributor.authorCebeci, Yıldız Uygun
dc.contributor.authorCeylan, Şule
dc.contributor.authorDemirbaş, Neslihan
dc.contributor.authorKaraoǧlu, Şenğül Alpay
dc.date.accessioned2021-03-30T13:10:34Z
dc.date.available2021-03-30T13:10:34Z
dc.date.issued2021en_US
dc.identifier.citationCebeci, Y. U., Ceylan, Ş., Demirbaş, N., Karaoǧlu, Ş. A. (2021). Conventional and microwave-assisted synthesis of novel 1,2,4-triazole derivatives containing tryptamine skeleton and evaluation of antimi-crobial activity, Letters in Organic Chemistry, 18 (2), 143- 155en_US
dc.identifier.urihttps://hdl.handle.net/11494/2869
dc.description.abstract1,2,4-Triazole-3-one (3) obtained from tryptamine was transformed to the corresponding car-box(thio)amides via several steps (6a-d). Their reaction with sodium hydroxide performed the 1,2,4-triazole derivatives (7a-d). Compounds 7a-d treatment by 2-bromo-1-(4-chlorophenyl)ethanoneain an ambiance with sodium ethoxide afforded the compounds (8a-d). The reduction reaction of 8a-d afforded 1,2,4-triazoles (9a-d). The synthesis of (10a-d), (11a-d) and (12a-d) was afforded treatment of products 9a-d with 4-chlorobenzyl chloride (for 10a-d) or 2,6-dichlorobenzyl chloride (for 11a-d) or 2,4-dichlorobenzyl chloride (for 12a-d). Besides the improved of entirely novel agents having various chemical features than those of the existing ones, another aim is to combined two or more groups into a single hybrid compound. For this reason, a single compound containing more than one group, each with various modes of effect, could be helpful for the cure of bacterial infections. Microwave-assisted and conventional techniques were utilized for the syntheses. The structures of recently obtained molecules were elucidated on the foundation of1H NMR,13C NMR, FT IR, EI MS methods and elemental analysis. All novel synthesized molecules were investigated for their antimicrobial activity using MIC (minimum inhibitory concentration) method. The aminoalkylation of triazoles (7a-d) formed products 8a-d which have excellent activity against testing bacteria with values between 0.24 and 125 µg/mL. Especially compounds 8a and 8d exhibited much better activity against E. coli than ampicillin used as standard drug. The microwave process ensured a more efficient road to the creation of desired mole-cules. The antibacterial examination demonstrated that after the carbonyl group is increased the anti-bacterial activity of the compounds is greatly increased. That's why molecules formed as a result of the alkylation reactions of triazoles has high activity.en_US
dc.language.isoengen_US
dc.publisherBentham Science Publishersen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,2,4-triazoleen_US
dc.subjectAntimicrobial activityen_US
dc.subjectHybrid compounden_US
dc.subjectMicrowaveen_US
dc.subjectTryptamineen_US
dc.titleConventional and microwave-assisted synthesis of novel 1,2,4-triazole derivatives containing tryptamine skeleton and evaluation of antimi-crobial activityen_US
dc.typearticleen_US
dc.relation.journalLetters in Organic Chemistryen_US
dc.departmentAÇÜ, Orman Fakültesien_US
dc.identifier.volume18en_US
dc.identifier.issue2en_US
dc.identifier.startpage143en_US
dc.identifier.endpage155en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitaka113Z181
dc.identifier.doi10.2174/1570178617999200721010921en_US
dc.contributor.institutionauthorCeylan, Şuleen_US


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