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dc.contributor.authorSaral, Sinan
dc.contributor.authorSaydam, Faruk
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorAtak, Mehtap
dc.contributor.authorTümkaya, Levent
dc.contributor.authorUydu, Hüseyin Avni
dc.date.accessioned2021-09-07T08:24:51Z
dc.date.available2021-09-07T08:24:51Z
dc.date.issued2021en_US
dc.identifier.citationSaral, S., Saydam, F., Dokumacioglu, E., Atak, M., Tümkaya, L., & Uydu, H. A. (2021). Effect of white tea consumption on serum leptin, TNF-α and UCP1 gene expression in ovariectomized rats. European Cytokine Network, 32(2), 31-38.en_US
dc.identifier.urihttps://hdl.handle.net/11494/3396
dc.description.abstractBackground: Obesity and dyslipidemia due to estrogen deficiency are among the important health problems in menopausal women. Increasing evidence reports the anti-obesity and anti-hyperlipidemic properties of tea polyphenols. However, the effect of white tea (WT) with high polyphenol content on overweight and lipid profile is uncertain. Here, we aimed to examine the effects of long-term WT consumption on serum leptin, tumor necrosis factor- alpha (TNF-α) and uncoupling protein 1 (UCP1) mRNA gene expression in ovariectomized (OVX) rats. Methods: Adult rats were divided into four groups (n = 8): (i) sham, (ii) OVX, (iii) WT and (iv) OVX + WT. WT was given at a dose of 0.5% w/v for 12 weeks. In the study, body weight, serum leptin, TNF, estradiol (E2) levels, lipid profile and UCP1 mRNA gene expression in brown adipose tissue (BAT) were evaluated. Results: There was a significant increase in body weight of OVX rats, which was decreased following WT consumption. While leptin and E2 levels decreased in the OVX group, TNF levels increased. There was no difference between the NF-κB levels of the groups. In addition, BAT UCP1 mRNA expression was significantly decreased in OVX groups, while WT treatment stimulated UCP1 activity. Conclusion: We explain the stimulatory effect of WT on weight loss mainly by the induction of UCP1 gene-mediated thermogenesis and suppression of inflammation. Therefore, we suggest that prolonged WT consumption may have beneficial effects in limiting excess weight gain caused by estrogen deficiency.en_US
dc.language.isoengen_US
dc.publisherJohn Libbeyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBody weighten_US
dc.subjectOvariectomizeden_US
dc.subjectTNF-αen_US
dc.subjectUCP1en_US
dc.subjectWhite teaen_US
dc.titleEffect of white tea consumption on serum leptin, TNF-α and UCP1 gene expression in ovariectomized ratsen_US
dc.typearticleen_US
dc.relation.journalEuropean Cytokine Networken_US
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.authorid0000-0002-2223-1331en_US
dc.identifier.volume32en_US
dc.identifier.issue2en_US
dc.identifier.startpage31en_US
dc.identifier.endpage38en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1684/ecn.2021.0467en_US
dc.contributor.institutionauthorDokumacıoğlu, Eda


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