Özdemir, Serap BaşoğluCebeci, Yıldız UygunBayrak, HacerMermer, ArifDemirbaş, AhmetKaraoğlu, Sengül AlpayDemirbaş, NeslihanCeylan, Şule2021-04-082021-04-082017Özdemir, S. B., Cebeci, Y. U., Bayrak, H., Mermer, A., Ceylan, S., Demirbaş, A., ... & Demirbaş, N. (2017). Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds. Heterocyclic Communications, 23(1), 43-54.https://doi.org/10.1515/hc-2016-0125https://hdl.handle.net/11494/2971Karadeniz Technical University, BAP, Turkey (Ref. No. 8623) is gratefully acknowledged.The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a-f was performed via the intermediary of triazoles 7a-c. The condensation of triazoles 7a-c with -several -heterocyclic amines in the presence of formalde-hyde afforded the corresponding N-aminoalkylated tria-zoles 11-14. The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reac-tions was examined. The synthesized compounds were screened for their antimicrobial activities.eninfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 3.0 United StatesAntimicrobial activityConazoleMannich baseMicrowavePiperazineArticle2314354N/A