Gümüş, Mustafa KemalKansız, SevgiTulemisova, Gulzhamal BagitovnaDege, NecmiSaif, Eiad2022-02-142022-02-142022Gümüş, M. K., Kansiz, S., Tulemisova, G. B., Dege, N., & Saif, E. (2022). Crystal structure and Hirshfeld surface analysis of 3-(hydroxymethyl)-3-methyl-2, 6-diphenylpiperidin-4-one. Acta Crystallographica Section E: Crystallographic Communications, 78(1), 29-32, 1.https://hdl.handle.net/11494/3718A new synthesis of the title compound, C19H21NO2, was developed with good yield and purity using the reaction of 4-hy­droxy-3-methyl-2-butanone, benzaldehyde and ammonium acetate in glacial acetic acid as a solvent. The central piperidine ring adopts a chair conformation, and its least-squares basal plane forms dihedral angles of 85.71?(11) and 77.27?(11)° with the terminal aromatic rings. In the crystal, the mol­ecules are linked by O-H?O and C-H?O hydrogen bonds into double ribbons. The Hirshfeld surface analysis shows that the most important contributions are from H?H (68%), C?H/H?C (19%) and O?H/H?O (12%) inter­actions.eninfo:eu-repo/semantics/openAccess4-hydroxy-3-methyl-2-butanoneAmmonium acetateBenzaldehydeCrystal structureHirshfeld surfaceHydrogen bondingPiperidoneArticle781293210.1107/S2056989021012640Q3N/A