Effect of oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetes

İskender, HaticeDokumacıoğlu, EdaTerim Kapakin, Kübra AsenaBolat, İsmailMokhtare, BehzatHayırlı, ArmağanYenice, Güler2023-02-202023-02-202023İskender, H., Dokumacıoğlu, E., Terim Kapakin, K. A., Bolat, I., Mokhtare, B., Hayırlı, A., & Yenice, G. (2023). Effect of Oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetes. Journal of Diabetes & Metabolic Disorders. ‌https://doi.org/10.1007/s40200-022-01178-xhttps://hdl.handle.net/11494/4714Diabetes mellitus (DM) is an important public health problem all over the world, considering its complications and increasing prevalence. Oleanolic acid (OA) has anti-diabetic property via modulating glucose metabolism and acting as 5?–adenosine monophosphate (AMP)–activated protein kinase (AMPK) / Sirtuin–1 (SIRT–1) activator and Interleukin 6 (IL–6) / Nuclear factor kappa B (NF–?B) inhibitor. This research questioned if the OA treatment amliorates the hepatic inflammatory profile in the diabetic ratseninfo:eu-repo/semantics/closedAccessAMPKDiabetesInflammationOleanolic acidSIRT-1Effect of oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetesArticle10.1007/s40200-022-01178-xN/AN/A