Subaş, TuğbaÖzgen, UfukKanbolat, ŞeydaBadem, MerveUzuner, UğurÖzdemir, GoncaZeytineli, ŞuleAltunışık, ŞeymaCangul, HalideEminağaoğlu, Özgür2025-06-232025-06-23202516121872https://hdl.handle.net/11494/5608The study aimed to investigate the anti-aging, skin-whitening, and antioxidant capacities of the extracts and constituents from the roots of Rosa canina L. by anti-collagenase, anti-tyrosinase activity, ferric-reducing antioxidant power (FRAP), cupric-reducing antioxidant capacity (CUPRAC) assays, and the Folin–Ciocalteu method (for the extracts). Enzyme inhibitory activities, pharmacokinetics, and drug-likeness properties of the compounds were evaluated in silico. According to the results of activity studies, the ethyl acetate subextract exhibited the highest anti-tyrosinase activity, and the remaining aqueous subextract demonstrated the highest anti-collagenase activity. The isolation studies led to the purification of euscaphic acid (1), tormentic acid (2), kaji-ichigoside F1 (3), rosamultin (4), 2-oxopomolic acid (5), and (+)-catechin (6) for the first time from the roots of this plant. Isolated compounds exhibited anti-collagenase and anti-tyrosinase activities. The extracts and (+)-catechin had higher antioxidant capacities than other compounds. R. canina roots and their compounds can be included in dermocosmetic products after further studies.eninfo:eu-repo/semantics/openAccessCosmeticIsolationMolecular dockingRosaceaeSwissADMEArticle10.1002/cbdv.2025003572-s2.0-10500820350640512464Q3WOS:001507635400001Q3