An efficient microwave-assisted synthesis of novel quinolone-triazole and conazole-triazole hybrid derivatives as antimicrobial and anticancer agents

Uygun Cebeci, YıldızCeylan, ŞuleAlpay Karaoğlu, ŞengülAltun, Muhammed2022-09-282022-09-282022Cebeci, Y. U., Ceylan, Ş., Karaoğlu, Ş. A., & Altun, M. (2022). An efficient microwave-assisted synthesis of novel quinolone-triazole and conazole-triazole hybrid derivatives as antimicrobial and anticancer agents. Journal of Heterocyclic Chemistry.https://hdl.handle.net/11494/42541,2,4-Triazole-fluoroquinolone and 1,2,4-triazole–conazole hybrids aredesigned, synthesized, and investigated in vitro against a variety of commondiseases. The structure of the newly synthesized compounds are characterizedfrom spectral data (IR,1H NMR,13C NMR, and LC–MS). The antibacterialactivity against both Gram-positive and Gram-negative bacteria is shown to beenhanced by many of the produced compounds. Also, some of the productsare found to have strong antiproliferative effects aganist HeLa cervical cancercells, whilst demonstrating cytotoxic effects toward normal cellseninfo:eu-repo/semantics/closedAccessAn efficient microwave-assisted synthesis of novel quinolone-triazole and conazole-triazole hybrid derivatives as antimicrobial and anticancer agentsArticle10.1002/jhet.4560Q2Q2