Ceylan, Şule2021-07-072021-07-072016Ceylan, Ş. (2016). Synthesis and biological evaluation of new Mannich and Schiff bases containing 1, 2, 4-triazole and 1, 3, 4-oxadiazole nucleus. Medicinal Chemistry Research, 25(9), 1958-1970.https://hdl.handle.net/11494/32745-(Pyridine-3-yl)-1, 3, 4-oxadiazole-2-thiole 2, obtaining starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases (3a–c) by the reaction with several heterocyclic amines in the presence of formaldehyde. 1,2,4-Triazole-3-thiole, (4) prepared from 1,3,4-oxadiazole-2-thiole (2) was converted to the corresponding Mannich bases (5a–e) by several steps. The synthesis of Schiff bases (6a–d) was performed from the reaction of the corresponding triazol-3-thioles with various aromatic aldehydes. The treatment of Schiff bases containing 1,2,4-triazoles 6c and 6d with morpholine or thiomorpholine generated the corresponding Mannich bases 7a, b and 8a, b. The synthesized compounds were screened for their antimicrobial, antilipase, and antiurease activities. Some of them were found to possess good-moderate antimicrobial, antiurease, and/or antilipase activity.eninfo:eu-repo/semantics/closedAccesss 1, 2, 4-Triazole1, 3, 4-OxadizoleNicotonic acid hydrazideMannich baseSchiff baseBiological activityArticle2591958197010.1007/s00044-016-1640-9Q1N/A