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dc.contributor.authorYamaç, Mustafa
dc.contributor.authorKanbak, Güngör
dc.contributor.authorZeytinoglu, Melih
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorDokumacıoğlu, Ali
dc.contributor.authorVan Griensven, Leo
dc.date.accessioned2019-12-31T08:17:00Z
dc.date.available2019-12-31T08:17:00Z
dc.date.issued2010en_US
dc.identifier.citationYamac, M., Kanbak, G., Zeytinoglu, M., Senturk, H., Bayramoglu, G., Dokumacioglu, A., & Van Griensven, L. J. L. D. (2010). Pancreas Protective Effect of Button Mushroom Agaricus bisporus (JE Lange) Imbach (Agaricomycetidae) Extract on Rats with Streptozotocin-Induced Dia betes. International Journal of Medicinal Mushrooms, 12(4).en_US
dc.identifier.urihttps://hdl.handle.net/11494/1899
dc.description.abstractIn the present study we describe the effects of hot water extract of the culinary-medicinal button mushroom, Agaricus bisporus, on the symptoms of streptozotocin-induced diabetes in Sprague Dawley rats. A. bisporus extract at the doses of 0, 100, 200, and 400 mg/kg body weight (bw) per day were orally applied to streptozotocin-induced diabetic rats for a period of 7 days after the onset of the diabetes. Food and water intake and body weight were recorded daily. Upon sacrifice, histological studies were performed on pancreas tissues, and biochemical parameters such as glucose, insulin superoxide dismutase, malondialdehyde and catalase were measured of all experimental groups. The serum glucose levels significantly decreased after oral administration at the dose of 400 mg/kg bw per day by 29.68% with A. bisporus extract. Furthermore, the serum insulin levels in the streptozotocin-induced diabetic rats were increased to 78.50% at the extract dose of 400 mg/kg bw per day. Also, catalase activities and malondialdehyde levels decreased to values slightly above the normal animal control. The most obvious and surprising change was, however, the increase in cellularity of the Langerhans islets of the pancreas and their apparent repopulation with beta cells. We conclude that the oral application of high doses of A. bisporus extract may result in decreased severity of streptozotocin-induced diabetes in rat.en_US
dc.language.isoengen_US
dc.publisherBegell Houseen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedicinal mushroomsen_US
dc.subjectAgaricus bisporusen_US
dc.subjectDiabetesen_US
dc.subjectHot water extracten_US
dc.subjectHypoglycemic effecten_US
dc.subjectPancreas histologyen_US
dc.subjectStreptozotocinen_US
dc.titlePancreas protective effect of button mushroom agaricus bisporus (je lange) ımbach (agaricomycetidae) extract on rats with streptozotocin-ınduced dia betesen_US
dc.typearticleen_US
dc.relation.journalInternational Journal of Medicinal Mushroomsen_US
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.authorid0000-0002-7262-0036en_US
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.identifier.startpage379en_US
dc.identifier.endpage389en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1615/IntJMedMushr.v12.i4.50en_US
dc.contributor.institutionauthorBayramoğlu, Gökhanen_US


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