Show simple item record

dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorDemiray, Özay
dc.contributor.authorDokumacıoğlu, Ali
dc.contributor.authorŞahin, Arzu
dc.contributor.authorŞen, Tuğba Mazlum
dc.contributor.authorCankaya, Mazlum
dc.date.accessioned2020-06-29T11:55:07Z
dc.date.available2020-06-29T11:55:07Z
dc.date.issued2018en_US
dc.identifier.citationDokumacıoğlu, E., Demiray, O., Dokumacıoğlu, A., Şahin, A., Şen, T. M., & Cankaya, S. (2018). Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder. Investigative and Clinical Urology, 59(4), 252-256.en_US
dc.identifier.urihttps://hdl.handle.net/11494/2132
dc.description.abstractPurpose: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation. Materials and Methods: A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease. Levels of MDA and 8-OHdG were measured in 24-hour urine samples for all subjects. Results: Urinary levels of MDA and 8-OHdG were significantly higher in the OAB group than in the control group (p<0.001). A significant positive correlation (p<0.001) was found between the measurements of 8-OHdG and MDA. Conclusions: Oxidative stress may be important in the pathophysiology of OAB, because levels of 8-OHdG and MDA are increased. Increased levels of 8-OHdG may be due to damaged nuclear and mitochondrial DNA as a result of oxidative attacks caused by free radicals. Nevertheless, further randomized and prospective studies with larger patient populations are neededen_US
dc.description.sponsorshipThis work was supported by Coordinator of Scientific Research Projects (2015.M80.02.04) at Artvin Coruh University.en_US
dc.language.isoengen_US
dc.publisherKorean Urological Assocen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectLipid peroxidationen_US
dc.subjectOxidative stressen_US
dc.subjectUrinary bladderen_US
dc.subjectoveractiveen_US
dc.subject8OHdGen_US
dc.titleMeasuring urinary 8-hydroxy-2'-deoxyguanosine and malondialdehyde levels in women with overactive bladderen_US
dc.typearticleen_US
dc.relation.journalInvestigative and Clinical Urologyen_US
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.authorid0000-0002-2223-1331en_US
dc.identifier.volume59en_US
dc.identifier.issue4en_US
dc.identifier.startpage252en_US
dc.identifier.endpage256en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4111/icu.2018.59.4.252en_US
dc.contributor.institutionauthorDokumacıoğlu, Edaen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess
Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess