dc.contributor.author | Bayramoğlu, Ayşegül | |
dc.contributor.author | Güneş, Hasan Veysi | |
dc.contributor.author | Metintaş, Muzaffer | |
dc.contributor.author | Degirmenci, İrfan | |
dc.contributor.author | Güler, Halil İbrahim | |
dc.contributor.author | Üstüner, Cengiz | |
dc.contributor.author | Musmul, Ahmet | |
dc.date.accessioned | 2020-11-09T05:46:43Z | |
dc.date.available | 2020-11-09T05:46:43Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Bayramoglu, A., Gunes, H. V., Metintas, M., Degirmenci, I., Guler, H. I., Ustuner, C., & Musmul, A. (2014). Plasminogen activator inhibitor-1 and susceptibility to lung cancer: a population genetics perspective. Genetic testing and molecular biomarkers, 18(8), 587-590. | en_US |
dc.identifier.uri | https://hdl.handle.net/11494/2425 | |
dc.description.abstract | Aim: The aim of this study was to investigate the polymorphism frequency of plasminogen activator inhibitor-1 (PAI-1) (rs1799889) 4G/5G in patients with lung cancer. Methods: In this study, 286 genomic DNAs (154 lung cancer patients + 132 subjects without lung cancer) were analyzed. Polymorphisms were determined by using the polymerase chain reaction (PCR) method, with 4G and 5G allele-specific primers. PCR products were assessed by a charge-coupled device camera and exposed to 2% agarose gel electrophoresis. Results: The frequencies of the PAI-1 gene 4G/5G genotypes were found to be 21% 4G/4G, 16% 4G/5G, and 62% 5G/5G in the control group and 31.4% 4G/4G, 30.8% 4G/5G, and 37.8% 5G/5G in the patient group. It was determined that the 5G/5G genotype frequency was high in patients in comparison with other genotypes. Conclusions: This study found a statistically significant difference between the groups with respect to genotype distribution. Consequently, we can say that the PAI-1 gene 4G/5G polymorphism is associated with lung cancer in Turkey. | en_US |
dc.description.sponsorship | Artvin Coruh University: 2011.M80.02.01 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Mary Ann Liebert Inc. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | [No Keywords Available] | en_US |
dc.title | Plasminogen activator inhibitor-1 and susceptibility to lung cancer: a population genetics perspective | en_US |
dc.type | article | en_US |
dc.relation.journal | Genetic Testing and Molecular Biomarkers | en_US |
dc.department | AÇÜ, Sağlık Bilimleri Fakültesi | en_US |
dc.authorid | 0000-0001-8567-807X | en_US |
dc.authorid | 0000-0002-7261-6790 | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 587 | en_US |
dc.identifier.endpage | 590 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1089/gtmb.2014.0061 | en_US |
dc.contributor.institutionauthor | Bayramoğlu, Ayşegül | en_US |