Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives
Künye
Balaydın, H. T., Şentürk, M., & Menzek, A. (2012). Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives. Bioorganic & Medicinal Chemistry Letters, 22(3), 1352-1357.Özet
The Naturally occurring novel cyclohexanonyl bromophenol 2(R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl)cyclohexanone (4) was synthesized as a racemic compound. Cyclohexylphenyl methane derivatives
(10–17) with Br, OMe, CO, and OH were also obtained. Inhibition of four human carbonic anhydrase
(hCA, EC 4.2.1.1) isozymes I, II, IV, and VI, with compounds 2–4, 8, and 10–26 was investigated. These
compounds were found to be promising carbonic anhydrase inhibitors and some of them showed interesting inhibitory activity. Some of the compounds investigated here showed effective hCA inhibitory
activity, and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological
disorders, and osteoporosis.