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dc.contributor.authorBakır, Tülay Özhan
dc.contributor.authorGeyikoğlu, Fatime
dc.contributor.authorÇolak, Suat
dc.contributor.authorTürkez, Hasan
dc.contributor.authorAslan, Ali
dc.contributor.authorBakır, Murat
dc.date.accessioned2020-11-13T08:35:25Z
dc.date.available2020-11-13T08:35:25Z
dc.date.issued2015en_US
dc.identifier.citationBakır, T. Ö., Geyikoğlu, F., Çolak, S., Türkez, H., Aslan, A., & Bakır, M. (2015). The effects of Cetraria islandica and Pseudevernia furfuracea extracts in normal and diabetic rats. Toxicology and Industrial Health, 31(12), 1304-1317.en_US
dc.identifier.urihttps://hdl.handle.net/11494/2454
dc.description.abstractLichens are symbiotic organisms composed of a fungus joined to a photosynthesizing partner that can be either an alga or a cyanobacterium. They can be used as a novel bioresource for natural antioxidants. However, there is also a need for further studies to validate the lichens used in medicinal remedies. This study covers a previously unrecognized effects of Cetraria islandica (CIAE) and Pseudeverniafurfuracea (PFAE) in streptozotocin (STZ)-induced diabetes. In experimental design, control or diabetic rats were either untreated or treated with aqueous lichen extracts (250-500 mg/kg/day) for 2 weeks starting at 72 h after STZ injection. On day 14, animals were anesthetized, metabolic and biochemical parameters were appreciated between control and treatment groups. The histopathology of kidney was examined using four different staining methods: hematoxylin-eosin (H&E), periodic acid-Schiff (PAS), Masson trichrome and Congo red. Our experimental data showed that increasing doses of CIAE and PFAE did not have any detrimental effects on the studied parameters and the malondialdehyde level of kidney. CIAE extract showed prominent results compared to doses of PFAE extract for antioxidant capacity. However, the protective effect of CIAE extract was inadequate on diabetes-induced disorders and kidney damages. Moreover, animals subjected to diabetes mellitus (DM) therapy did not benefit unfortunately from the usage of increasing lichen doses due to their unchanged antioxidant activity to tissue. The results obtained in present study suggested that CIAE and PFAE are safe but the power of these is limited because of the intensive oxidative stress in kidney of type 1 diabetic rats. It is also implied that CIAE extract is especially suitable for different administration routes in DM.en_US
dc.description.sponsorshipThis work was financially supported by Ataturk University.en_US
dc.language.isoengen_US
dc.publisherSage Publicationsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCetraria islandicaen_US
dc.subjectPseudevernia furfuraceaen_US
dc.subjectDiabetes mellitusen_US
dc.subjectKidneyen_US
dc.subjectHistologyen_US
dc.subjectOxidative stressen_US
dc.titleThe effects of Cetraria islandica and Pseudevernia furfuracea extracts in normal and diabetic ratsen_US
dc.typearticleen_US
dc.relation.journalToxicology and Industrial Healthen_US
dc.departmentAÇÜ, Rektörlüken_US
dc.identifier.volume31en_US
dc.identifier.issue12en_US
dc.identifier.startpage1304en_US
dc.identifier.endpage1317en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1177/0748233713475521en_US
dc.contributor.institutionauthor[0-Belirlenecek]en_US


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