Cycloaddition of enamines with 1,4-dimethoxy-2-butyne and 2-butyne-1,4-diol mediated by titanium tetrachloride
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CitationUludağ, N., Yarapsanlı, Y., Asutay, O., & Gümüş, M. K. (2018). Cycloaddition of Enamines with 1, 4-Dimethoxy-2-butyne and 2-Butyne-1, 4-diol Mediated by Titanium Tetrachloride. Organic Preparations and Procedures International, 50(4), 441-448.
Enamines are versatile compounds capable of alkylations, acylations, cycloadditions and annulation cascades. They are also involved in a range of heterocycle-forming processes.1,2 The broad applicability of heterocyclic secondary enamines in synthesis has been amply demonstrated in the past two decades.3,4 The reaction conditions, yield and nature of enamine ring-opening have received great attention in the literature.