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dc.contributor.authorGümüş, Mustafa Kemal
dc.contributor.authorGorobets, Nikolay Yu.
dc.contributor.authorSedash, Yuriy V.
dc.contributor.authorShishkina, Svitlana V.
dc.contributor.authorDesenko, Sergey M.
dc.date.accessioned2021-04-02T08:42:23Z
dc.date.available2021-04-02T08:42:23Z
dc.date.issued2017en_US
dc.identifier.citationGümüş, M. K., Gorobets, N. Y., Sedash, Y. V., Shishkina, S. V., & Desenko, S. M. (2017). Rapid formation of chemical complexity via a modified Biginelli reaction leading to dihydrofuran-2 (3H)-one spiro-derivatives of triazolo [1, 5-a] pyrimidine. Tetrahedron Letters, 58(35), 3446-3448.en_US
dc.identifier.urihttps://hdl.handle.net/11494/2908
dc.descriptionThe work was supported by Artvin Coruh University research project (BAP-2012.F19.02.23) and Mevlana Exchange Program (MEV-2016-027).en_US
dc.description.abstractThe regio- and stereoselective, catalyst-free multicomponent synthesis of spiro-conjugated dihydrofuran-2(3H)-one/triazolo[1,5-a]pyrimidine derivatives in good to high yields via a Biginelli approach starting from ortho-substituted benzaldehydes, 3-amino-1.2,4-triazole and alpha-acetylbutyrolactone is reported. A plausible reaction mechanism for this transformation is discussed. The obtained heterocycles possess a drug-like conformationally restricted structure with defined stereochemistry and increased stability compared to other products obtained by this mode of the Biginelli reaction.en_US
dc.language.isoengen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectModified Biginelli reactionen_US
dc.subjectClean synthesisen_US
dc.subjectMulticomponent reactionen_US
dc.subjectDihydrofuran-2(3H)-oneen_US
dc.subjectTriazolo[1,5-a]pyrimidineen_US
dc.subjectSpiro-compoundsen_US
dc.titleRapid formation of chemical complexity via a modified Biginelli reaction leading to dihydrofuran-2(3H)-one spiro-derivatives of triazolo[1,5-a]pyrimidineen_US
dc.typearticleen_US
dc.relation.journalTetrahedron Lettersen_US
dc.departmentAÇÜ, Eğitim Fakültesien_US
dc.authorid0000-0001-6373-5221en_US
dc.identifier.volume58en_US
dc.identifier.issue35en_US
dc.identifier.startpage3446en_US
dc.identifier.endpage3448en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.tetlet.2017.07.071en_US
dc.contributor.institutionauthor[0-Belirlenecek]en_US


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