Ara
Toplam kayıt 9, listelenen: 1-9
Synthesis and antimicrobial activities of hybrid heterocyclic molecules based on 1-(4-fluorophenyl) piperazine skeleton
(Bentham Science Publishers, 2017)
Background: The amine (2) was prepared starting from 1-(4-fluorophenyl) piperazine via two steps, and then converted to the corresponding hydrazide (4). The reaction of hydrazide (4) with carbon disulfide generated the ...
Microwave-assisted synthesis of some hybrid molecules derived from morpholine and investigation of their antimicrobial activities
(Wiley-VCH Verlag GmbH, 2017)
2H-1,2,4-triazol-3(4H)-one compound was obtained starting from 4-(2-fluoro-4-nitrophenyl)morpholine via several steps. Then, these compounds were converted to the corresponding fluoroquinolone hybrids via one pot three ...
Microwave-assisted synthesis of novel mannich base and conazole derivatives containing biologically active pharmacological groups
(Bentham Science Publishers, 2021)
Background: The aim of this study was to synthesize new Mannich bases and conazol derivatives with biological activity by the microwave-assisted method. Introduction: 1,2,4-Triazole-3-one (3) acquired from tryptamine was ...
Microwave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeleton
(Walter De Gruyter Gmbh, 2016)
Carbothioamides 4a,b, obtained from nalidixic acid, were converted to the corresponding 1,3-thiazolidine derivatives 5a,b by cyclocondensation with 2-bromo-1-(4-chlorophenyl)ethanone. Treatment of 4a,b with base afforded ...
Novel microwave assisted synthesis and antimicrobial activity of new quinolone-hybrids
(Bentham Science Publ Ltd, 2016)
Background: Carbo(thio)amid derivatives 4a, 4b were obtained starting from nalidixic acid in three steps. The acidic treatment of compound 4a generated the corresponding 1,3,4-oxadiazole (5), while the compound 4a gave ...
Synthesis and antimicrobial, antiproliferative evaluation of novel quinolone and conazole analogues via conventional and microwave techniques
(John Wiley and Sons Inc, 2021)
1,2,4-Triazole-3-one (3), acquired from cinnamaldehyde was converted to the corresponding carbox(thio)amides via several steps (6 a–c). Their reaction with sodium hydroxide gave the 1,2,4-triazole derivatives (7 a–c). ...
Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus
(Springer Birkhauser, 2013)
2-[6-(Morpholin-4-yl)pyridin-3-ylamino]acetohydrazide (4) was obtained starting from 6-morpholin-4-ylpyridin-3-amine (2) via the formation of ester (3) and then converted to the corresponding Schiff bases (5, 6) with the ...
Conventional and microwave-assisted synthesis of novel 1,2,4-triazole derivatives containing tryptamine skeleton and evaluation of antimi-crobial activity
(Bentham Science Publishers, 2021)
1,2,4-Triazole-3-one (3) obtained from tryptamine was transformed to the corresponding car-box(thio)amides via several steps (6a-d). Their reaction with sodium hydroxide performed the 1,2,4-triazole derivatives (7a-d). ...
Conventional and microwave irradiated synthesis, biological activity evaluation of highly substituted indole-triazole hybrids
(Elsevier B.V., 2021)
In the present study, a series of new indole-3-carbaldehyde embedded triazole derivatives have been synthesized. 4-{[(1E)-1H-indol-3-ylmethylidene]amino}-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (2) were converted to ...