dc.contributor.author | Çiçek, Ayşegül Çopur | |
dc.contributor.author | Düzgün, Azer Özad | |
dc.contributor.author | Saral, Ayşegül | |
dc.contributor.author | Sandallı, Cemal | |
dc.date.accessioned | 2021-10-11T07:15:28Z | |
dc.date.available | 2021-10-11T07:15:28Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Çiçek, A. C., Düzgün, A. O., Saral, A., & Sandallı, C. (2014). Determination of a novel integron‐located variant (bla OXA‐320) of Class D β‐lactamase in Proteus mirabilis. Journal of Basic Microbiology, 54(10), 1030-1035. | en_US |
dc.identifier.uri | https://hdl.handle.net/11494/3517 | |
dc.description | This work was partially supported by Recep Tayyip Erdogan University Research Fund Grants BAP-2009.102.03.2 and BAP-2011.102.03.3. | en_US |
dc.description.abstract | Proteus mirabilis (P. mirabilis) is one of Gram-negative pathogens encountered in clinical specimens. A clinical isolate (TRP41) of P. mirabilis was isolated from a Turkish patient in Turkey. The isolate was identified using the API 32GN system and 16S rRNA gene sequencing and it was found resistant to ampicillin/sulbactam, piperacillin, tetracycline, and trimethoprim/sulfamethoxazole. This isolate was harboring a Class 1 integron gene cassette and its DNA sequence analysis revealed a novel bla(OXA) variant exhibiting one amino acid substitution (Asn266Ile) from bla(OXA-1). This new variant of OXA was located on Class 1 integron together with aadA1 gene encoding aminoglycoside-modifying enzymes. According to sequence records, the new variant was named as bla(OXA-320). Cassette array and size of integron were found as bla(OXA-320)-aadA1 and 2086bp, respectively. The bla(OXA-320) gene is not transferable according to conjugation experiment. In this study, we report the first identification of bla(OXA-320)-aadA1 gene cassette, a novel variant of Class D -lactamase, in P. mirabilis from Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | bla(OXA-320) gene | en_US |
dc.subject | Class D -lactamase | en_US |
dc.subject | Integron | en_US |
dc.subject | P | en_US |
dc.subject | mirabilis | en_US |
dc.title | Determination of a novel integron-located variant (bla(OXA-320)) of Class D beta-lactamase in Proteus mirabilis | en_US |
dc.type | article | en_US |
dc.relation.journal | Journal of Basic Microbiology | en_US |
dc.department | AÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü | en_US |
dc.authorid | 0000-0002-7757-6812 | en_US |
dc.identifier.volume | 54 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.startpage | 1030 | en_US |
dc.identifier.endpage | 1035 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1002/jobm.201300264 | en_US |
dc.contributor.institutionauthor | Saral, Ayşegül | |