Protective effects of Echinacea purpurea in an acetic acid induced rat model of colitis
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Erişim
info:eu-repo/semantics/openAccessTarih
2012Yazar
Bayramoğlu, GökhanŞentürk, Hakan
Dokumacıoğlu, Ali
Aral, Erinç
Kanbak, Güngör
İnal, Mine
Oğlakçı, Ayşegül
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Senturk, H., Bayramoglu, G., Dokumacioglu, A., Erinc, A. R. A. L., Kanbak, G., Mine, İ. N. A. L., & Oglakci, A. (2012). Protective effects of Echinacea purpurea in an acetic acid induced rat model of colitis. Biyolojik Çeşitlilik ve Koruma, 5(2), 59-65.Özet
In order to investigate putative protective effects of Echinacea purpurea on colonic inflammation, we
determined Adenosine deaminase (ADA) and superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels
and protein carbonyl contents were determined in colonic tissues of rats in the colitis and colitis plus Echinacea
purpurea (at different doses 50,100 mg/kg) given rats. Besides, histopathology of colon tissues were evaluated. In the
Echinacea treatment groups (50 and 100 mg/kg doses) ADA activities were significantly decreased as compared to
acetic acid group, but there was no statistically significant between two treatment groups (p>0.05). Echinacea treatment
also was decreased MDA levels at two doses according to colitis group (p<0.05). There was no statistically significant
between two treatment groups (p>0.05). Slightly decreased protein carbonyl contents and elevated SOD activities were
shown in the two Echinacea therapy groups as compared to acetic acid induced colitis group. But these were not
statistically significant (p>0.05). Similar observations were recorded for these parameters in the extracts of colonic
tissue specimens. The results revealed that pretreatment to colitic rats with Echinacea purpurea at doses of 50 and 100
mg/kg, partially attenuated the colonic damage induced by acetic acid. In conclusion, the preventive effects of
Echinacea purpurea in the acetic acid model of rat colitis is probably related to its antioxidant properties, due to its
flavonoid content.