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  • Küçük Resim
    Öğe
    The effects of lichens extracts in the healthy rats and the medical utility of these extracts in the prevention of diabetes-associated multiple organ failures
    (Kafkas Univ, 2015) Çolak, Suat; Geyikoğlu, Fatime; Türkez, Hasan; Bakır, Murat; Husseinigouzdaganii, Mirkhalil; Can, Serpil; Çığşar, Gülşen; Aslan, Ali
    In the present study, we firstly assessed Cetraria islandica and Pseudevernia furfuracae to avoid detrimental effects on multiple tissues of rats. Diabetes mellitus (DM) with the subsequent generation of oxidative stress represents a major risk factor for organs. The second aim of this study is to investigate whether administration of both lichens could prevent type 1 diabetes (T1D)-induced organ dysfunctions. During two weeks, both control and diabetic rats were treated with aqueous lichen extracts. The metabolic changes were determined. On day 14, after animals were decapitated, required samples for biochemical and genetic analysis were collected. Oxidative damage of DNA was estimated by measuring the increase in 8-hydroxy-2'-deoxyguanosine formation. Biochemical parameters were used to observe and evaluate the functional changes in tissues. Experimental data showed that the increasing doses of lichens alone have not any detrimental effect on above parameters. Moreover, C. islandica decreased the diabetes-induced glucose and malondialdehyde (MDA) levels. Thus, it seemed that the antioxidant treatment has an important effect on the organ failure in ill rats. However, the protective effect of C. islandica was inadequate on diabetes-induced disorders and DNA damages. Lichens are a safe in the studied dose range but the power of C. islandica is limited because of intensive oxidative stress in essential organs of T1D rats.
  • Küçük Resim
    Öğe
    Hepatoprotective effects of B-1,3-(D)-Glucan on bortezomib-induced liver damage in rats
    (Kafkas Univ, 2014) Keleş, Osman Nuri; Can, Serpil; Çığşar, Gülşen; Çolak, Suat; Erol, Hüseyin Serkan; Akaras, Nurhan; Erdemci, Burak; Bilgin, Bülent Çağlar; Can, İsmail; Ünal, Bünyamin; Halıcı, Mesut Bünyamin
    The aim of this study was to evaluate the effects of beta -1,3-(D)-glucan as an antioxidant and tissue protective agent and study the biochemical, histopathologic, and immunohistochemical effects of first therapeutic proteasome inhibitor bortezomib on the liver for treating relapsed multiple myeloma. The experiment included 36 adult male rats, which were divided into four treatment groups: control (healthy); bortezomib-treated; beta-1,3-D-glucan-treated; and bortezomib + beta-1,3-(D)-glucan-treated. Each group was subdivided into two subgroups based on time of sacrifice (48 or 72 h). After the experiments, superoxide dismutase (SOD) activity and lipid peroxidation (LPO) amounts were determined, and immunohistochemical and histopathological changes were examined in all rat liver tissues. beta -1,3-(D)-Glucan treatment normalized changes of LPO and stimulated an over activity of endogenous SOD. The results of the histopathologic parameters showed that treatment with beta -1,3-(D)-Glucan in the bortezomib group ameliorated the development of non-specific reactive hepatitis (NSRH) and Kupffer cell activation via NF-kB. Administration of beta -1,3-(D)-Glucan is effective in reversing tissue damage induced by bortezomib in rat livers.