Yazar "Chebanov, Valentyn A." seçeneğine göre listele

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    In Vitro Cytotoxicity of Methano[1,2,4]Triazolo-[1,5-C][1,3,5]Benzoxadiazocine Derivatives and Their Effects on Nitrite and Prostaglandin E2 (PGE2) Levels
    (Springer, 2022) Doğan, İnci Selin; Gümüş, Mustafa Kemal; Gorobets, Nikolay Yu; Reis, Rengin; Orak, Duygu; Sipahi, Hande; Sarı, Suat; Chebanov, Valentyn A.
    Biological activity of the Biginelli type heterocycles is extremely broad and provides a suitable platform for the discovery of potent small drug-like molecules. Such activity of 3,4-dihydropyrimidin-2(1H)-one (DHPM) derivatives is widely known, whereas their oxygen-bridged analogs, benzoxadiazocines, are presented quite rarely in the literature. In this study, a series of new methano[1,2,4]triazolo[1,5-c][1,3,5]benzoxadiazocine derivatives (3a-3j) were evaluated in vitro for their activities and molecular docking features. According to the molecular docking study, COX-2 and PGE(2)S appeared as likely targets responsible for the reduced PGE(2) levels caused by the title compounds. The cytotoxicity of compounds 3a-3g, 3j was evaluated on RAW 264.7 murine macrophage cell line by MTT assay after treatment for 24 h with various doses (25, 50, 100 mu M) of these compounds. Then, compounds admitting cell viability higher than 70% were tested for their anti-inflammatory activity at non-toxic doses by evaluating the nitrite level of cell supernatants with the Griess reagent. Compounds 3c and 3f demonstrated significant inhibition of nitrite production (by 29 and 25%, respectively) at 100 mu M (p < 0.05). These compounds significantly inhibited PGE(2) production, thus suggesting analgesic activity.
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    Molecular diversity of lupane hybrids in drug design and materials science
    (Multidisciplinary Digital Publishing Institute (MDPI), 2025) Lipson, Victoria V.; Shirobokova, Maria G.; Gümüş, Mustafa Kemal; Öztürkcan, Arda; Chebanov, Valentyn A.
    The need for new, more effective drugs to treat cancer, infectious diseases, various parasitic infestations, and metabolic disorders requires innovative approaches to the design of promising molecules. One of these areas is the creation of hybrid structures. Lupane triterpenoids are of significant interest for such research due to their high abundance in natural sources and their renewable nature, their molecular architecture, presence of several easily modifiable functional groups, enantiomeric purity, broad spectrum of biological activity, and low toxicity. Active research into the biological properties of new pentacyclic triterpenoid derivatives, not only of the lupane series but also of the oleonane and ursane series, is evidenced by the large number of reviews and experimental studies devoted to this topic. Our interest in the modification of lupanoids stems not only from the search for biologically active compounds but also from the development of functional materials. However, the materials science aspects of lupanoid applications are virtually unknown in literature. We have tried to fill this gap and examined the possibility of using betulin derivatives to create advanced materials. The high lipophilicity and nanoscale molecular structure of these compounds make them highly promising as chiral dopants in liquid crystal compositions and organogel components.