Yazar "Turan, İbrahim" seçeneğine göre listele

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  • Küçük Resim
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    Investigation of antioxidant and antidiabetic activities of different extracts of Vitis labrusca fruit peels
    (WILEY, 2025) Canbolat Gültekin, Deniz; Akmeşe, Osman; Gültekin, Ergün; Erşen Bak, Funda; Özkan, Ahmet İsmail; Turan, İbrahim; Demir, Selim; Aliyazıcıoğlu, Yüksel
  • Küçük Resim
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    Investigation of antioxidant and antidiabetic activities of propolis obtained from different locations of Artvin
    (WILEY, 2025) Turan, İbrahim; Canbolat Gültekin, Deniz; Akmeşe, Osman; Gültekin, Ergün; Demir, Selim; Aliyazıcıoğlu, Yüksel
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    Öğe
    School for Tribes
    (Edizioni Universita Macerata, 2013) Demirel, Fatih; Turan, İbrahim
    During his rule, Sultan Abdulhamid II (r. 1876-1909) had to recover as a financially, militarily, and politically sick of European man. After losing vast Christian territories in the Balkans he also had to initiate Pan-Islamic politics to protect unity and cope with European driven liberalist movements among the Arabs. Knowing that education is the most important factor in development and community enlightenment, Sultan Abdulhamid II attempted to reform and expand the Ottoman educational system by establishing several educational institutions for various purposes during his reign. Among them, the "Royal School for Tribes", established in 1892 in Istanbul, is distinguished from others with its aims and students.
  • Küçük Resim
    Öğe
    The ameliorative effect of Primula vulgaris on cisplatin-induced nephrotoxicity in rats and quantification of its phenolic components using LC-ESI-MS/MS
    (Elsevier B.V., 2023) Turan, İbrahim; Canbolat, Deniz; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel
    Cisplatin (CDDP) is an important chemotherapeutic agent, accumulation of which in kidney tissue causes nephrotoxicity and renal failure. The aim of this study was to evaluate, for the first time in the literature, the protective effect of dimethyl sulfoxide (DMSO) extract of Primula vulgaris leaf (PVE) against CDDP-induced nephrotoxicity in rats. The PVE content was characterized using liquid chromatography-mass spectrometry. Nephrotoxicity was induced with a single dose of CDDP (7.5 mg/kg). Thirty female Wistar-Albino rats were divided into five groups (control, DMSO, CDDP (7.5 mg/kg), CDDP + PVE (25 mg/kg), and CDDP + PVE (50 mg/kg)). Biochemical and histopathological analyses were then performed. Rutin, gallic acid, p-coumaric acid and protocatechuic acid were identified as major components of PVE. Total antioxidant status and glutathione (GSH) values increased significantly in the serum samples from the treatment group compared to the CDDP group, while blood urea nitrogen, creatinine, oxidative stress index, malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), total oxidant status, and 8-hydroxy-2′-deoxyguanosine (8-OHdG) values decreased significantly. GSH levels increased significantly in the treatment group compared to the CDDP group, while TNF-α, caspase-3, 8-OHdG, MDA levels and damage scores decreased significantly. In conclusion, PVE exhibited strong protective effects through its anti-apoptotic, antioxidant, and anti-inflammatory activities against nephrotoxicity and oxidative damage caused by CDDP in rats.