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    Comparison of athletic performance of Turkish ice hockey players with ACE I/D (rs1799752), ACTN3 (rs1815739), PPARA (rs4253778) and HIF1A (rs11549465) polymorphisms
    (Cellular and Molecular Biology, 2024) Sercan Doğan, Canan; Akkoç, Orkun; Özağır, Meltem; Avcı, Sinan; Biçer Baikoğlu, Selin; Kurudirek, Muhammet İrfan; Ulucan, Korkut
    Our study is aimed at examining the Ice Hockey National Team players with regard to ACE I/D (rs1799752), ACTN3 (rs1815739), PPARA (rs4253778) and HIF1A (rs11549465) polymorphisms and physical tests. This study was participated by 21 players from ice hockey national team. While ACE I/D (rs1799752) polymorphism was obtained using conventional polymerase chain reaction method (PCR), ACTN3 (rs1815739), PPARA (rs4253778) and HIF1A (rs11549465) polymorphisms were produced by real time polymerase chain reaction method (qPCR). Athletic performance analysis, on the other hand, was based on the assessment of maximal oxygen consumption capacity (VO2max), anaerobic performance, flexibility and strength tests. In our cohort, ACE I/D (rs1799752) polymorphism was determined as 24% genotype II, 33% genotype ID, and 43% genotype DD. ACTN3 (rs1815739) polymorphism was determined as 24% genotype RR, 43% genotype RX, and 33% genotype XX. PPARA (rs4253778) polymorphism was observed as 71% genotype GG, 14.5% genotype GC, 14.5% genotype CC. HIF1A (rs11549465) polymorphism was found to be 67% genotype CC, 33% genotype CT. Concerning physical tests, the evaluation of flexibility test results among genotype groups did not yield significant differences (p=0.365). No significant difference was found among genotype groups with respect to leg strength test results (p=0.691). The evaluation of handgrip strength test results among genotype groups did not reveal significant differences (p=0.679). No significant differences were found among genotype groups when VO2 max test results were examined (p=0.686). A significant relationship was found in the speed test and HIF1A rs11549465 polymorphism evaluation (p = 0.008). No significant results were detected when comparing the speed test with other polymorphisms (p = 0.65). The results of our study support the previous studies which had focused on the potential relation between the relevant gene polymorphisms and athletic performance of ice hockey players. However, doing further studies with larger cohorts is recommended in order to understand the relationship between the relevant polymorphisms and athletic performance of ice hockey players.
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    The determination of the relationship between Vo2max and the angiotensin-converting enzyme gene (ace) rs1799752 polymorphisms ın the Turkish national ıce hockey sports team
    (2023) Doğan, Canan Sercan; Polat, Tolga; Akkoç, Orkun; Kurudirek, Muhammet İrfan; Ulucan, Korkut
    In the present study, the effect of ACE rs1799752 polymorphism on maximal oxygen consumption (VO2max) in ice hockey players was analyzed. For this reason, 21 male National Ice Hockey players, aged between 18-25, were recruited for the study. The conventional polymerase chain reaction (PCR) was used on the genotype rs1799752 polymorphism. The VO2max values were calculated by using the 20m Shuttle Run tests. The numbers and percentages of the II, ID and DD genotypes were 9 (%43), 7 (%33), and 5 (%24), respectively. The allelic distribution for I and D alleles was found to be 25 (60%) and 17 (40%), respectively. The mean VO2max of all the athletes was calculated as 47.52 ml. The mean VO2max of the II, ID, and DD genotypes were 49.74ml, 47.34 ml, and 46.43 ml, respectively. We found that the oxygen utilization capacity increased from the DD genotype to the II genotype. However, this increase was not statistically significant (p> 0.05). In order to confirm our findings, it is recommended that larger prospective studies depending on the effect of the relevant polymorphisms needed to be carried out.