Association of methylenetetrahydrofolate reductase rs1801133 genetic variants with type 2 diabetes mellitus and diabetic nephropathy

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dc.authoridGökhan Bayramoğlu / 0000-0003-2779-6478en_US
dc.authoridMustafa Çağatay Korkmaz / 0000-0003-3302-0705en_US
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorGüler, Halil İbrahim
dc.contributor.authorÇoban, Nezaket
dc.contributor.authorKorkmaz, Mustafa Çağatay
dc.date.accessioned2022-12-23T09:30:51Z
dc.date.available2022-12-23T09:30:51Z
dc.date.issued2022
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, İş Sağlığı ve Güvenliği Bölümüen_US
dc.description.abstractBackground: Type 2 diabetes mellitus (T2DM) is a complex metabolic disease with a genetic predisposition. Methylenetetrahydrofolatereductase (MTHFR) gene is one of the candidate genes associated with T2DM and diabetic nephropathy (DN). This research was carried out to determine the frequency of the C677T polymorphism (rs1801133) of the MTHFR gene and examine the role of rs1801133 polymorphism in T2DM and DN development.Methods: DNA was obtained from peripheral blood samples (273 samples) using a DNA isolation kit. MTHFR rs1801133 polymorphism was determined using polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), and electrophoresis. PCR products were cut by restriction enzyme HiNF I and analyzed by 2% agarose gel electrophoresis. The results were statistically analyzed.Results: Although MTHFR rs1801133 genotype frequencies showed statistically significant differences between the control and T2DM patient groups (p = 0.001), no statistically significant difference was found between individuals with and without DN.Conclusions: MTHFR gene rs1801133 polymorphism is related to T2DM but not to DN. CT and TT genotypes can be accepted as genetic markers.
dc.identifier.citationAssociation of Methylenetetrahydrofolate Reductase rs1801133 Genetic Variants with Type 2 Diabetes Mellitus and Diabetic Nephropathy. (2022). Makara Journal of Health Research, 26(2).en_US
dc.identifier.doi10.7454/msk.v26i2.1352
dc.identifier.endpage80en_US
dc.identifier.issue2en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.7454/msk.v26i2.1352
dc.identifier.urihttps://hdl.handle.net/11494/4308
dc.identifier.volume26en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorBayramoğlu, Gökhan
dc.institutionauthorKorkmaz, Mustafa Çağatay
dc.language.isoenen_US
dc.publisherUniv Indonesiadirectorate Research & Publicen_US
dc.relation.ispartofMakara Journal of Health Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetic nephropathyen_US
dc.subjectGenetic variationen_US
dc.subjectMethylenetetrahydrofolate reductaseen_US
dc.subjectRestriction fragment length polymorphismen_US
dc.subjectType 2 diabetes mellitusen_US
dc.titleAssociation of methylenetetrahydrofolate reductase rs1801133 genetic variants with type 2 diabetes mellitus and diabetic nephropathyen_US
dc.typeArticle

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