Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
Yükleniyor...
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter De Gruyter Gmbh
Erişim Hakkı
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivs 3.0 United States
Attribution-NonCommercial-NoDerivs 3.0 United States
Özet
The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a-f was performed via the intermediary of triazoles 7a-c. The condensation of triazoles 7a-c with -several -heterocyclic amines in the presence of formalde-hyde afforded the corresponding N-aminoalkylated tria-zoles 11-14. The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reac-tions was examined. The synthesized compounds were screened for their antimicrobial activities.
Açıklama
Karadeniz Technical University, BAP, Turkey (Ref. No. 8623) is gratefully acknowledged.
Anahtar Kelimeler
Antimicrobial activity, Conazole, Mannich base, Microwave, Piperazine
Kaynak
Heterocyclic Communications
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
23
Sayı
1
Künye
Özdemir, S. B., Cebeci, Y. U., Bayrak, H., Mermer, A., Ceylan, S., Demirbaş, A., ... & Demirbaş, N. (2017). Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds. Heterocyclic Communications, 23(1), 43-54.
