Synthesıs of hetaryl substituted pyrazolo[3,4- b]quinolinone systems by multicomponent cyclocondensation reaction
| dc.authorid | 0000-0001-6373-5221 | en_US |
| dc.authorid | 0000-0003-4795-1375 | en_US |
| dc.contributor.author | Gümüş, Mustafa Kemal | |
| dc.contributor.author | Kaban, Şeniz | |
| dc.date.accessioned | 2024-12-23T08:11:40Z | |
| dc.date.available | 2024-12-23T08:11:40Z | |
| dc.date.issued | 2024 | |
| dc.department | AÇÜ, Artvin Meslek Yüksekokulu, Laboratuvar Teknolojisi Bölümü | en_US |
| dc.description.abstract | In this study, the synthesis of pyrazolo[3,4-b]quinolinone compounds was carried out via one-pot three-component reactions. These reactions proceed as domino processes, making them easier to occur than the conventional multistep organic reactions. By employing this method, new organic molecules can be synthesized in a single step, using minimal time and number of trials. In the first phase of this two-step study, heteroaromatic carbaldehydes (quinoline-8-carboxaldehyde and quinoline-4-carboxaldehyde) were prepared to be used as substrates in subsequent reactions by oxidation of 8-methylquinoline and 4-methylquinoline with selenium dioxide, a mild oxidant. In the second step, heteroaromatic carbaldehyde reacted with aminopyrazole and dimedone in anhydrous ethanol by one-pot multicomponent condensation method to synthesize six compounds with heteryl-substituted pyrazolo[3,4-b]quinolinone ring system. The crude products were obtained in excellent yields and further purified by crystallization. The structures of the compounds, which were found to be completely pure as a result of chromatographic studies, were elucidated by spectroscopic methods and elemental analysis. | |
| dc.identifier.doi | 10.34248/bsengineering.1545551 | |
| dc.identifier.endpage | 1216 | en_US |
| dc.identifier.issue | 6 | en_US |
| dc.identifier.startpage | 1204 | en_US |
| dc.identifier.uri | http://dx.doi.org/10.34248/bsengineering.1545551 | |
| dc.identifier.uri | https://hdl.handle.net/11494/5232 | |
| dc.identifier.volume | 7 | en_US |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Black Sea Journal of Engineering and Science | |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | One-Pot Reactions | en_US |
| dc.subject | Quinolinone | en_US |
| dc.subject | Selenium Dioxide | en_US |
| dc.subject | Methylquinoline | en_US |
| dc.subject | Multicomponent Reactions (MCRs) | en_US |
| dc.subject | Biological Activity | en_US |
| dc.title | Synthesıs of hetaryl substituted pyrazolo[3,4- b]quinolinone systems by multicomponent cyclocondensation reaction | en_US |
| dc.type | Article |
