Microwave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeleton

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dc.contributor.authorCeylan, Şule
dc.contributor.authorBayrak, Hacer
dc.contributor.authorÖzdemir, Serap Başoğlu
dc.contributor.authorUygun, Yıldız
dc.contributor.authorMermer, Arif
dc.contributor.authorDemirbaş, Neslihan
dc.contributor.authorÜlker, Serdar
dc.date.accessioned2021-07-06T10:45:44Z
dc.date.available2021-07-06T10:45:44Z
dc.date.issued2016
dc.departmentAÇÜ, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümüen_US
dc.description.abstractCarbothioamides 4a,b, obtained from nalidixic acid, were converted to the corresponding 1,3-thiazolidine derivatives 5a,b by cyclocondensation with 2-bromo-1-(4-chlorophenyl)ethanone. Treatment of 4a,b with base afforded 1,2,4-triazoles 6a,b. The synthesis of 1,3-oxazolidine 7 was performed by the reaction of compound 4a with ethyl bromoacetate. Treatment of 4a with acid produced 1,3,4-thiadiazole 8. The reaction of compounds 6a and 6b with several heterocyclic amines in the presence of formaldehyde gave the corresponding Mannich bases 9–15 containing various pharmacophore groups. Conventional and microwave-assisted methods were used for the synthesis. The effect of an acid catalyst on Mannich reactions was investigated. The structures of the newly synthesized compounds were elucidated on the basis of 1H NMR, 13C NMR, FTIR, EIMS techniques, and elemental analysis. All compounds were screened for their antimicrobial activity.
dc.identifier.citationCeylan, S., Bayrak, H., Ozdemir, S. B., Uygun, Y., Mermer, A., Demirbas, N., & Ulker, S. (2016). Microwave-assisted and conventional synthesis of novel antimicrobial 1, 2, 4-triazole derivatives containing nalidixic acid skeleton. Heterocyclic Communications, 22(4), 229-237.en_US
dc.identifier.doi10.1515/hc-2016-0019
dc.identifier.endpage237en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage229en_US
dc.identifier.urihttps://hdl.handle.net/11494/3267
dc.identifier.volume22en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Şule
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofHeterocyclic Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitak113Z181
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject1,2,4-triazoleen_US
dc.subjectAntimicrobial activityen_US
dc.subjectMannich baseen_US
dc.subjectNalidixic aciden_US
dc.subjectNorfloxacinen_US
dc.titleMicrowave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeletonen_US
dc.typeArticle

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