Responses of aortic ring vascular smooth muscle in rats with hyperthyroidism to phenylephrine and potassium chloride

Basit Öğe Kaydı
dc.authorid0000-0002-0042-890Xen_US
dc.contributor.authorÜstündağ, Hilal
dc.contributor.authorŞentürk, Esra
dc.contributor.authorÇelebi, Fikret
dc.contributor.authorGül, Mustafa
dc.date.accessioned2020-02-05T13:57:38Z
dc.date.available2020-02-05T13:57:38Z
dc.date.issued2018
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractAim: The effects of thyroid hormones on receptor numbers and pharmacological contractile responses of vascular smooth muscle appear to be controversial. The aim of the present study was to evaluate the vascular responses to potassium chloride (KCl) and phenylephrine (PE) in a rat model of hyperthyroidism
dc.description.abstractMethods:The study was approved by the Ethical Committee of The Animal Research of Ataturk University. Wistar Albino type of rats were divided into two groups: Control (n=5) and hyperthyroidism(n=5). Hyperthyroidism was induced by intraperitoneal injection of L-thyroxine (0.3mg/kg/day) for two-weeks. The thoracic aorta rings suspended in an isolated organ bath with Krebs-Henseleit buffer. Maximal tension was measured in response to KCl and PE in rings with intact endothelium. The data were evaluated by one-way ANOVA with post-hoc Tukey test.
dc.description.abstractResults:Our results showed that contractile responses of the aortic rings of with hyperthyroidism to PE (10-7M) were significantly reduced compared to the control group (1.34±0.43g, 3.26±0.39g, respectively, p<0.05). Vascular response to 40 mM KCl show that, slight decrease in the hypethyroidism group relative to control (1.89±0.19g, 2.17±0.14g vs, respectively).
dc.description.abstractConclusions: The decrease in the vascular response in this study suggests the decrease in vascular resistance in hyperthyroidism, and can be explained in part by changes in endothelial cell function.
dc.identifier.citationÜstündağ, H., Şentürk, E., Çelebi, F., & Gül, M., (2018). Responses of Aortic Ring Vascular Smooth Muscle in Rats with Hyperthyroidism to Phenylephrine and Potassium Chloride . Turkish Society of Physiological Sciences 44th National Physiology Congress, Antalya, Turkeyen_US
dc.identifier.endpage45en_US
dc.identifier.issueSIen_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://hdl.handle.net/11494/1944
dc.identifier.volume225en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorÜstündağ, Hilal
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofActa Physiologica
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keywords Available]en_US
dc.titleResponses of aortic ring vascular smooth muscle in rats with hyperthyroidism to phenylephrine and potassium chlorideen_US
dc.typeOther

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Hemşirelik Bölümü Yayın Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu