Synthesis and antimicrobial, antiproliferative evaluation of novel quinolone and conazole analogues via conventional and microwave techniques

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dc.contributor.authorCeylan, Şule
dc.contributor.authorUygun Cebeci, Yıldız
dc.contributor.authorAlpay Karaoğlu, Şengül
dc.contributor.authorAltun, Muhammed
dc.date.accessioned2021-10-06T08:05:38Z
dc.date.available2021-10-06T08:05:38Z
dc.date.issued2021
dc.departmentAÇÜ, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümüen_US
dc.description.abstract1,2,4-Triazole-3-one (3), acquired from cinnamaldehyde was converted to the corresponding carbox(thio)amides via several steps (6 a–c). Their reaction with sodium hydroxide gave the 1,2,4-triazole derivatives (7 a–c). Compound 3 treatment with 2-bromo-1-(4-chlorophenyl) ethanone or 2-chloro-1-(2,4-dichlorophenyl)ethanone afforded the compounds 8 a,b and by reducing these compounds reduction products were obtained (9 a,b). The synthesis of (10 a–e) was carried out by the reaction compounds 9 a,b with different benzyl chlorides. Then oxadiazole derivative (12) was obtained by ring closure from hydrazide compound 5. Subsequently compounds 3, 7 a–c, and 12 were treated with various amines in the presence of formaldehyde to yield Mannich bases (11 a–e, 14 a–e, 13 a,b). Microwave-assisted and conventional techniques were utilized for the syntheses. The structures of newly synthesized compounds were illuminated by spectroscopic methods. Their antimicrobial (MIC method), and anticancer activities (Abay's method) were examined. Results showed that most of the compounds exhibited good antimicrobial activities. Especially compounds 14 a–e which is a mannich base showed very good antitubercular activity against Mycobacterium smegmatis compared with Streptomycin standard drug. Also compounds 8 a and 9 b have been found to have strong antiproliferative effects on the HeLa cervical cancer cells and also these compounds did not have a cytotoxic effects on a normal cells.
dc.identifier.citationCeylan, Ş., Cebeci, Y. U., Demirbaş, N., Karaoğlu, Ş. A., & Altun, M. (2021). Synthesis and Antimicrobial, Antiproliferative Evaluation of Novel Quinolone and Conazole Analogues via Conventional and Microwave Techniques, ChemistrySelect, 6(35), 9467-9476.en_US
dc.identifier.doi10.1002/slct.202101840
dc.identifier.endpage9476en_US
dc.identifier.issue35en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage9467en_US
dc.identifier.urihttps://hdl.handle.net/11494/3508
dc.identifier.volume6en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Şule
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject1,2,4-triazoleen_US
dc.subjectAnticanceren_US
dc.subjectAntimicrobial activityen_US
dc.subjectMannich baseen_US
dc.subjectQuinoloneen_US
dc.titleSynthesis and antimicrobial, antiproliferative evaluation of novel quinolone and conazole analogues via conventional and microwave techniquesen_US
dc.typeArticle

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