Synthesis and antimicrobial activities of hybrid heterocyclic molecules based on 1-(4-fluorophenyl) piperazine skeleton

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dc.contributor.authorÖzdemir, Serap Başoğlu
dc.contributor.authorDemirbaş, Neslihan
dc.contributor.authorCebeci, Yıldız Uygun
dc.contributor.authorBayrak, Hacer
dc.contributor.authorMermer, Arif
dc.contributor.authorDemirbaş, Ahmet
dc.contributor.authorCeylan, Şule
dc.date.accessioned2021-04-15T06:54:31Z
dc.date.available2021-04-15T06:54:31Z
dc.date.issued2017
dc.departmentAÇÜ, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümüen_US
dc.descriptionKaradeniz Technical University, BAP, Turkey (Ref. No. 8623) and is gratefully acknowledged.en_US
dc.description.abstractBackground: The amine (2) was prepared starting from 1-(4-fluorophenyl) piperazine via two steps, and then converted to the corresponding hydrazide (4). The reaction of hydrazide (4) with carbon disulfide generated the corresponding 1,3,4-oxadiazole (5), while the treatment of hydrazide with ethyl bromoacetate produced 4-oxo-2-thioxo-1,3-thiazolidine compound (6). The four-component condensation of 4 with several aldehydes gave the corresponding 4-oxo-2-thioxo-1,3-thiazolidinglycinamides (7a-f). Methods: The synthesis of 4-oxo-1,3-oxazolidines (9a, b), 1,3-oxazoles (10a, b) and 1,3,4-triazoles (11a, b) was carried out starting from compounds 8a, b. Mannich bases (12a-d and 13a-f) were prepared using three component condensation of compounds 5 and 12a, b and corresponding amines. The synthesis of 16a-c, which were considered as the new analogues of azole class antifungals, was performed starting from the compound 14a via three steps. Results and Conclusion: All the reactions were examined under traditional and microwave irradiation conditions, and optimum conditions were defined. The antimicrobial activities of the newly synthesized compounds were screened and some of the tested compounds were displayed good-moderate antibacterial activity.
dc.identifier.citationÖzdemir, S. B., Demirbaş, N., Cebeci, Y. U., Bayrak, H., Mermer, A., Ceylan, S., & Demirbaş, A. (2017). Synthesis and antimicrobial activities of hybrid heterocyclic molecules based on 1-(4-fluorophenyl) piperazine skeleton. Letters in Drug Design & Discovery, 14(9), 1014-1034.en_US
dc.identifier.endpage1034en_US
dc.identifier.issue9en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage1014en_US
dc.identifier.urihttps://hdl.handle.net/11494/2980
dc.identifier.volume14en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Şule
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.relation.ispartofLetters in Drug Design & Discovery
dc.relation.isversionof10.2174/1570180814666170113145023en_US
dc.relation.isversionof10.2174/1570180814666170113145023
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitak113Z181
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFluorophenyl piperazineen_US
dc.subjectHybrid compounden_US
dc.subjectMulticomponenten_US
dc.subjectMicrowaveen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAcidsen_US
dc.titleSynthesis and antimicrobial activities of hybrid heterocyclic molecules based on 1-(4-fluorophenyl) piperazine skeletonen_US
dc.typeArticle

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