Conventional and microwave irradiated synthesis, biological activity evaluation of highly substituted indole-triazole hybrids

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dc.contributor.authorUygun Cebeci, Yıldız
dc.contributor.authorCeylan, Şule
dc.contributor.authorAlpay Karaoğlu, Şengül
dc.date.accessioned2021-12-02T13:14:05Z
dc.date.available2021-12-02T13:14:05Z
dc.date.issued2021
dc.departmentAÇÜ, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümüen_US
dc.description.abstractIn the present study, a series of new indole-3-carbaldehyde embedded triazole derivatives have been synthesized. 4-{[(1E)-1H-indol-3-ylmethylidene]amino}-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (2) were converted to the corresponding Mannich bases containing flouroquinolone core via a one-pot, three-component reaction. The synthesis of conazole analogues was carried out starting from triazoles by three steps. Reactions were carried out under conventional and microwave-mediated conditions. Various catalysts and solvents were tested to see how they affected conventional and microwave (MW)-induced reactions. The antibacterial characteristics of all the newly synthesized compounds were tested, and the majority of them showed good to moderate activity. The most significant result of our investigation is the high activity of fluoroquinolone derivative compounds that we synthesized as hybrid molecules.
dc.identifier.citationCebeci, Y. U., Ceylan, Ş., & Karaoğlu, Ş. A. (2021). Conventional and Microwave Irradiated Synthesis, Biological Activity Evaluation Of Highly Substituted Indole-Triazole Hybrids. Journal of Molecular Structure, 131799.en_US
dc.identifier.doi10.1016/j.molstruc.2021.131799
dc.identifier.issn0022-2860
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11494/3577
dc.identifier.volumeArticle in pressen_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Şule
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,2,4-triazoleen_US
dc.subjectFluoroquinoloneen_US
dc.subjectConazoleen_US
dc.subjectAntimicrobial activityen_US
dc.titleConventional and microwave irradiated synthesis, biological activity evaluation of highly substituted indole-triazole hybridsen_US
dc.typeArticle

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